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unreviewed

CPT-1

0 reactions · 0 pathways

What it does, reaction by reaction

0 reactions

This enzyme appears only in the regulation table, with no catalysed step recorded.

What accelerates and inhibits it

Regulation is pathway-specific, so each context is listed separately

2 entries

Beta-Oxidation of Fatty Acids

Accelerated by

Low malonyl-CoA; increased fatty-acyl-CoA supply

Inhibited by

Malonyl-CoA (potent allosteric inhibitor)

Hormonal control

Glucagon/epinephrine favor oxidation indirectly by lowering ACC activity and malonyl-CoA; insulin raises malonyl-CoA and restrains CPT-1

Ketogenesis

Accelerated by

Low malonyl-CoA, fatty-acyl-CoA availability

Inhibited by

Malonyl-CoA

Hormonal control

Glucagon/epinephrine lower malonyl-CoA and increase fatty-acid entry; insulin opposes this

Recent literature

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Europe PMC · from cache · sorted by publication date

  1. 1
    Danshen-Chuanxiong alleviates cerebral ischemia by regulating carnitine metabolism and angiogenesis via activating CPT1/HIF-1α signaling axis.

    Pang HQ, Zhang XH, Zhang JL, Zhang L, Zhao YJ, Yan YP, Lu X, Yan BC. · 2026-07-10

    unreviewed
  2. 2
    Multi-omics characterization of glucose-lipid metabolic remodeling associated with Gymnema sylvestre (Retz.) R.Br. ex Sm. treatment in a type 2 diabetic mouse model.

    Zeng Z, Liu Y, Xiao G, Jia C, Wu M, Li Y, Jiang J, Zhang J, Xu A, Bi X. · 2026-06-20

    unreviewed
  3. 3
    Soil-derived microbiota induces T regulatory cells and protect against mouse colitis, metabolic disease, and sepsis.

    Szurek EA, Ngo VL, Abo H, Cebula A, Chassaing B, Howard RA, Hart M, Hori S, Weaver CT, Gewirtz AT, Ignatowicz… · 2026-05-24

    open access unreviewed
  4. 4
    Alcohol consumption in metabolic dysfunction-associated steatotic liver disease (MASLD): understanding the gut-liver crosstalk for clinical translation.

    Benedé-Ubieto R, Estévez-Vázquez O, Acar R, Leal-Lassalle H, Gutierrez AH, Redondo-Urzainqui A, Iborra S, Odi… · 2026-02-21

    cited 2× open access unreviewed
  5. 5
    Multi-omics dissection of metabolic hijacking: Infectious bronchitis virus orchestrates lipid-centric replication through PPAR-TGF-β crosstalk.

    Yan K, Wang X, Bo Z, Zhang C, Guo M, Zhang X, Wu Y. · 2026-01-28

    cited 1× open access unreviewed
  6. 6
    cAMP-PKA/EPAC signaling pathways: crucial regulators of lipid homeostasis.

    Chen C, Gao H, Tian Q, Cao J. · 2026-01-07

    open access unreviewed
  7. 7
    Dietary arginine modulates growth performance and testicular development across life stages in male swimming crab (<i>Portunus trituberculatus</i>).

    Li X, Xu T, Deng Y, Zhan W, Xie S, Cui X, Zou Y, Zhu T, Jin M, Zhou Q. · 2026-06-06

    unreviewed
  8. 8
    RRBP1 promotes osimertinib resistance by activating fatty acid oxidation-dependent metabolic and immune reprogramming in EGFR-Mutant lung adenocarcinoma.

    Huang Y, Zhang Y. · 2026-06-12

    unreviewed
  9. 9
    Urea cycle dysregulation and arginine pathways in the pathogenesis of NAFLD and NASH (Review).

    Zhu B, Wang C, Liu P, Qu Z, Qi R, Chen S, Niu H. · 2026-06-11

    open access unreviewed
  10. 10
    Dietary fat type modulates fatty acid digestibility, de novo lipogenesis, and energy expenditure in broiler chickens.

    Wongsuthavas S, Wanapat M, Yuangklang C, Vasupen K, Wongtrairat W, Khonkhaeng B, Khotsakdee J, Beynen AC. · 2026-05-05

    open access unreviewed

External claims. These come from an index outside this database and are not checked against it. Treat them as leads.