Hexokinase I–III
What it does, reaction by reaction
This enzyme appears only in the regulation table, with no catalysed step recorded.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
Glycolysis
Availability of glucose
Glucose-6-phosphate
No major acute direct hormonal regulation
Recent literature
Europe PMC · fetched just now · sorted by publication date
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1
G6PC2 controls glucagon secretion by defining the set point for glucose in pancreatic α cells.
Bahl V, Rifkind R, Waite E, Hamdan Z, May CL, Manduchi E, Voight BF, Lee MYY, Tigue M, Manuto N, Glaser B, Av… · 2025-01-01
cited 7× unreviewed -
2
Conserved glucokinase regulation in zebrafish confirms therapeutic utility for pharmacologic modulation in diabetes.
Schmitner N, Thumer S, Regele D, Mayer E, Bergerweiss I, Helker C, Stainier DYR, Meyer D, Kimmel RA. · 2024-11-23
cited 5× open access unreviewed -
3
Biomarkers of autoimmunity and beta cell metabolism in type 1 diabetes.
Yang ML, Kibbey RG, Mamula MJ. · 2022-10-27
cited 9× open access unreviewed -
4
Glucokinase intrinsically regulates glucose sensing and glucagon secretion in pancreatic alpha cells.
Moede T, Leibiger B, Vaca Sanchez P, Daré E, Köhler M, Muhandiramlage TP, Leibiger IB, Berggren PO. · 2020-11-19
cited 34× open access unreviewed -
5
When a Little Bit More Makes the Difference: Expression Levels of GKRP Determines the Subcellular Localization of GK in Tanycytes.
Salgado M, Ordenes P, Villagra M, Uribe E, García-Robles MLA, Tarifeño-Saldivia E. · 2019-03-29
cited 2× open access unreviewed -
6
Predictive blood glucose lowering efficacy by Glucokinase activators in high fat fed female Zucker rats.
Coope GJ, Atkinson AM, Allott C, McKerrecher D, Johnstone C, Pike KG, Holme PC, Vertigan H, Gill D, Coghlan M… · 2006-08-21
cited 57× unreviewed -
7
Zonation of gluconeogenesis, ketogenesis and intracellular pH in livers from normal and diabetic ketoacidotic rats: evidence for intralobular redistribution of metabolic events in ketoacidosis.
Burns SP, Cohen RD, Iles RA, Bailey RA, Desai M, Germain JP, Going TC. · 1999-10-01
cited 12× unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.