gamma-Glutamyl carboxylase (GGCX)
Cofactors used
Clinical / pharmacological. Carboxylates factors II, VII, IX, X, protein C, S, Z
What it does, reaction by reaction
Vitamin K Cycle Cofactor & Vitamin Metabolism · ER membrane
Glutamate residue + CO2 + O2 + vitamin K hydroquinone -> gamma-carboxyglutamate + vitamin K epoxide
Converts Glutamate residue CO2 O2 Vitamin K hydroquinone into gamma-carboxyglutamate Vitamin K epoxide
› Notes
Gla residues chelate Ca2+ and anchor factors II, VII, IX, X and proteins C, S and Z to phospholipid membranes; also osteocalcin and matrix Gla protein.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
Europe PMC · from cache · sorted by publication date
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1
Author Correction: GGCX promotes Eurasian avian-like H1N1 swine influenza virus adaption to interspecies receptor binding.
Zou J, Jiang M, Xiao R, Sun H, Liu H, Peacock T, Tu S, Chen T, Guo J, Zhao Y, Barclay W, Xie S, Zhou H. · 2026-08-03
unreviewed -
2
Systemic administration of interleukin-10 is associated with dose-dependent toxicities in Wistar albino rats.
Kato CD, Angom DY, Kisaka S, Mugasa CM, Matovu E, Namayanja M, Nabisubi P, Ssekatawa K. · 2026-06-15
unreviewed -
3
Syndrome of High Gamma-Glutamyl Transferase in Racehorses.
Haughan J, Cathcart J, Tomlinson JE. · 2026-06-05
unreviewed -
4
Neonatal Kasai portoenterostomy for biliary atresia: Clinical characteristics and outcomes.
Tian Y, Chen S, Yu Chung PH, Ye M, Liu C, Chen Y, Ji J, Li X, Tam PKH, Li L. · 2026-05-25
unreviewed -
5
Gamma-glutamyl Transferase and Triglycerides Associated with an Early Food Intake Response to Anamorelin in Gastrointestinal Cancer Cachexia.
Kurahashi T, Hosui A, Hiramatsu N. · 2026-07-25
unreviewed -
6
Immunoresponsive Gene 1-Itaconate Exacerbates Hypertension by Inhibiting the Cystathionine Gamma-Lyase/Hydrogen Sulfide Pathway.
Ma M, Fan C, Han S, Wang H, Xue Y, Lv B, Huang H, Jin H, Jin L, Liu J. · 2026-07-20
unreviewed -
7
Systematic Identification of Therapeutic Targets and Repurposed Drugs for Stroke: From Genome Causal Analysis to Multilevel Validation.
Zhang X, Zhang YM, Li JL, Wang W, Tu WJ, Wang HQ. · 2026-06-23
unreviewed -
8
Bioengineered baculovirus-derived extracellular vesicles loaded with of γ-carboxylated Gla-rich protein: Dual modulation of inflammation and vascular calcification.
Viegas C, Pichard S, Carreira J, Ova A, Troffer-Charlier N, Maia TM, Edelweiss E, Macedo AL, Matos A, Faria T… · 2026-03-18
unreviewed -
9
Evaluating the Diagnostic Value of Clinical and Laboratory Parameters in Older Adults with Abdominal Pain: A Retrospective Analysis of CT Predictors.
Akyar D, Bayram N, Onur OE, Akoglu H, Denizbasi A. · 2026-06-29
unreviewed -
10
Oxidative Stress Biomarkers and Systemic Inflammatory Indices in Metabolic Dysfunction-Associated Steatotic Liver Disease with Type 2 Diabetes Mellitus: A Comparative and Longitudinal Analysis
Pădureanu V, Boldeanu L, Bobîrcă A, Clenciu D, Pădureanu R, Mitrea A, Gheorman V, Pătrașcu Ș, Vladu B, George… · 2026-06-01
open access unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.