gamma-Glutamyl carboxylase (GGCX)
Cofactors used
Clinical / pharmacological. Carboxylates factors II, VII, IX, X, protein C, S, Z
What it does, reaction by reaction
Vitamin K Cycle Cofactor & Vitamin Metabolism · ER membrane
Glutamate residue + CO2 + O2 + vitamin K hydroquinone -> gamma-carboxyglutamate + vitamin K epoxide
Converts Glutamate residue CO2 O2 Vitamin K hydroquinone into gamma-carboxyglutamate Vitamin K epoxide
› Notes
Gla residues chelate Ca2+ and anchor factors II, VII, IX, X and proteins C, S and Z to phospholipid membranes; also osteocalcin and matrix Gla protein.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
Europe PMC · fetched just now · sorted by publication date
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1
γ-glutamyl carboxylase inhibition by Anisindione.
Zhou N, Wang R, Chen B, Li J, Tie JK, Liu F, Qi X. · 2026-08-27
unreviewed -
2
Pharmacogenetic, Clinical, Prescribing, and Demographic Predictors of Sertraline Pharmacokinetics.
de la Cruz CG, Thomas L, Mata-Martín C, Villatoro-García JA, de Andrés F, González-Rodríguez I, González-Mart… · 2026-09-09
open access unreviewed -
3
Admission Liver Injury Is an Independent Predictor of Early and Overall Mortality in Hospitalized Patients with Moderate-to-Critical COVID-19: A Retrospective Cohort Study.
Negru-Vodă DI, Stemate A, Negreanu L. · 2026-09-16
open access unreviewed -
4
Discriminative Performance of Routine Inflammation- and Nutrition-Based Indices for Histopathologically Confirmed Gastric Malignancy: A Retrospective Case-Control Study.
Bilici M, Ayvaz D, Güney D, Yüce ÜI, Aydemir S. · 2026-09-16
open access unreviewed -
5
ADAR1 and ADAR2 Expression in the Thoracic Aortic Wall Correlates with Aneurysm Severity and Dissection Risk: Insights into A-to-I RNA Editing Dysregulation in Marfan Syndrome-Derived vSMCs.
Pisano C, Colopi A, Silvestris DA, Terriaca S, Guida E, Porreca A, Sbrigata A, Doronzio PN, Orlandi A, Dolci … · 2026-09-16
open access unreviewed -
6
Echocardiographic Evaluation of Systolic and Diastolic Cardiac Functions in Pediatric Cirrhosis: Unmasking Subclinical Alterations and Correlation with Liver Severity Scores.
Öncül M, Güngör Ş, Elkıran Ö, Varol Fİ, Gök E, Tat F, Bayram H, Erdoğan S, Güngör ED, Öncül Y. · 2026-09-08
open access unreviewed -
7
Bilirubin and the Yellow Players in Ferroptosis: A Delicate Balance in Human Health and Disease, with a Focus on the Liver, Cardiovascular System, and Brain.
Dalla Verde C, Vitek L, Tiribelli C, Gazzin S. · 2026-09-21
open access unreviewed -
8
Molecular Mechanisms of Obesity-Associated Oxidative Stress and Therapeutic Strategies.
Wang R, Luo Y, Liu L, Zhang J, Li R, Zhang N. · 2026-09-18
open access unreviewed -
9
Transcriptomic Landscape of Gut Microbiota-Host Interactions Reveals Domestication-Related Changes in the Pearl Oyster <i>Pinctada maxima</i>.
Huang J, Zhang T, Xie D, Zheng Z, Yang C, Liao Y, Wang Q, Deng Y. · 2026-09-10
open access unreviewed -
10
Gamma-Glutamyl Transferase at the Crossroads of Cardiometabolic Disease and Metabolic Dysfunction-Associated Steatotic Liver Disease.
Kozyk M, Strubchevska O, Strubchevska K, Kothari MM, Peterson SJ, Frishman WH, Aronow WS. · 2026-09-10
unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.