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unreviewed

beta-Ketothiolase (acyl-CoA acetyltransferase)

1 reactions · 1 pathways

Cofactors used

CoA-SH · B5 (Pantothenic acid)

What it does, reaction by reaction

1 reactions

Beta-Oxidation of Fatty Acids Lipid Metabolism · Mitochondrial matrix (peroxisome for VLCFA)

step 8 Irreversible/directional

3-Ketoacyl-CoA + CoA-SH → acetyl-CoA + fatty acyl-CoA shortened by two carbons

Converts 3-Ketoacyl-CoA CoA-SH into Acetyl-CoA

› Notes

β-Ketothiolase (acyl-CoA acetyltransferase) performs thiolysis. The shortened acyl-CoA re-enters steps 5–8 until the chain is fully converted to acetyl-CoA; for an even-chain saturated fatty acid, the final thiolysis yields two acetyl-CoA molecules.

Showing all 1 reactions.

What accelerates and inhibits it

Regulation is pathway-specific, so each context is listed separately

0 entries

No regulation recorded for this enzyme in the source documents.

Recent literature

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Europe PMC · fetched just now · sorted by publication date

  1. 1
    Circadian reprogramming of inflammation and metabolism in chronic kidney disease.

    Li XQ, Cheng L, Chen TF, Ma YN, Li XH, Fu TY, Xiao J, Zhao ZZ. · 2026-09-06

    open access unreviewed
  2. 2
    Branched-chain amino acids and gut microbiota: coregulation and impact on neurological function via the gut-brain axis.

    Li Q, Fan B, Xiao Y, Zhang Z, Zhao S, Liao B, Zeng J, Shan X, Ye H, Wen Y, Zhang L, Guo H, Xiao F, Zhu H. · 2026-07-14

    open access unreviewed
  3. 3
    The Crimean-Congo haemorrhagic fever virus hijacks the liver lipid metabolic pathway for virion production.

    Gautam A, Zhong L, Ogire E, Bodoirat S, Riedmiller I, Sander WJ, Boson B, Gandhi A, Burlaud-Gaillard J, Amira… · 2026-03-30

    open access unreviewed
  4. 4
    Gut microbiota metabolic reprogramming drives the development of metabolic diseases in the host.

    Wang Y, Huang B, Wei X, Guan Y, Li L, Zheng Y, Sun W. · 2026-03-14

    cited 40× open access unreviewed
  5. 5
    Lactate induces renal lipid accumulation and aggravates renal fibrosis by inhibiting the PPARα signaling pathway and fatty acid oxidation.

    Wang W, Gao Y, Chen Y, Cheng M, Wei L, Sang Y, Zhang L, Dai R, Wang Y. · 2026-03-10

    open access unreviewed
  6. 6
    Research progress on lysine acetylation (Review).

    Zhang M, Zhang Y, Yin H, Yan J, Dong Y, Zhao X, Cui T, Lv B, Gao X. · 2026-09-04

    open access unreviewed
  7. 7
    Research progress in metabolic reprogramming and targeting metabolic pathways for clear cell renal cell carcinoma.

    Yao JT, Hu PC, Li XW, Xu JC, Wang KJ, Ye SZ, Meng XY, Chen HC, Liang Y, Ma Q. · 2025-12-19

    open access unreviewed
  8. 8
    Ketogenic Diet–Associated Remodeling of the Cortical Proteome in Rats With Genetic Absence Epilepsy

    Gunel A, Guler U, Toplu A, Acikgoz N, Onat B, Moniri A, Salih B, Sezerman O, Onat F. · 2026-10-01

    open access unreviewed
  9. 9
    Metabolic effects of periodontal pathogens <i>Fusobacterium nucleatum</i> and <i>Porphyromonas gingivalis</i> in colorectal cancer cells.

    Gopinath D, Selvakumar B, Sekar P, Mohammed MM, Li Z. · 2026-09-24

    open access unreviewed
  10. 10
    Propionate promotes CD8&lt;sup&gt;+&lt;/sup&gt; T-cell infiltration and enhances immunotherapy efficacy in colorectal cancer.

    Pan J, Tong L, Fei R, Wu K, Ji J, Sun T, Zhao Y, Zhang J, Feng H, Hua H, Yao HP. · 2026-10-01

    open access unreviewed

External claims. These come from an index outside this database and are not checked against it. Treat them as leads.