beta-Ketothiolase (acyl-CoA acetyltransferase)
Cofactors used
What it does, reaction by reaction
Beta-Oxidation of Fatty Acids Lipid Metabolism · Mitochondrial matrix (peroxisome for VLCFA)
3-Ketoacyl-CoA + CoA-SH → acetyl-CoA + fatty acyl-CoA shortened by two carbons
Converts 3-Ketoacyl-CoA CoA-SH into Acetyl-CoA
› Notes
β-Ketothiolase (acyl-CoA acetyltransferase) performs thiolysis. The shortened acyl-CoA re-enters steps 5–8 until the chain is fully converted to acetyl-CoA; for an even-chain saturated fatty acid, the final thiolysis yields two acetyl-CoA molecules.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
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