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unreviewed

beta-Ketoacyl-ACP synthase (KS) domain of FAS

1 reactions · 1 pathways

Cofactors used

ACP

What it does, reaction by reaction

1 reactions

Fatty Acid Synthesis (De Novo Lipogenesis) Lipid Metabolism · Cytosol

step 8 Irreversible/directional

Acetyl-KS + malonyl-ACP → acetoacetyl-ACP + CO2

Converts Acetyl-KS Malonyl-ACP into Acetoacetyl-ACP CO2

› Notes

The β-ketoacyl-ACP synthase (KS) domain catalyzes decarboxylative condensation, producing a four-carbon β-ketoacyl-ACP. No ATP is consumed in this condensation; decarboxylation of malonyl-ACP provides the thermodynamic drive. In subsequent rounds, the growing acyl chain replaces acetyl-KS.

Showing all 1 reactions.

What accelerates and inhibits it

Regulation is pathway-specific, so each context is listed separately

0 entries

No regulation recorded for this enzyme in the source documents.

Recent literature

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Europe PMC · fetched just now · sorted by publication date

  1. 1
    Mitochondria-related pathogenic genes in acute and chronic kidney disease: a Mendelian randomization study.

    Wang J, Yuan T, Wei Q, Xie K, Zhang J. · 2026-07-08

    unreviewed
  2. 2
    Enhanced lactose utilization from milk enriched in Uridine-5'-monophosphate drives hepatic energy storage in young mammals.

    Gao LM, Liu L, Yang XD, Long CM, Wu X. · 2026-06-01

    open access unreviewed
  3. 3
    STARD10 promotes progression of HER2+ breast cancer and intracellular lipid metabolism via the cAMP/PKA/CREB1 signaling axis.

    Liu S, Gao J, Niu Y, Dong X, Zhang Z, Teng X, Li Z, Zhang S, Meng Y, Gao MQ. · 2026-06-15

    open access unreviewed
  4. 4
    MITF-Driven melanoma plasticity as a core mechanism of therapy resistance: integrating microenvironmental signaling, mechanotransduction, and metabolic reprogramming.

    Kisielewska M, Suwała S, Drąg-Zalesińska M, Rembiałkowska N. · 2026-06-15

    open access unreviewed
  5. 5
    Integrated transcriptome and metabolome reveal <i>Mycoplasma hyopneumoniae</i> -induced lipid accumulation, inflammation, oxidative stress, and energy imbalance in the liver of pigs.

    Xue X, Bu Y, Yu C, Li J, Yang J, Gao M, Wang P, Gan Y, Zhang W, Fan S, Zhou R, Yin Z, Zheng X. · 2026-06-03

    open access unreviewed
  6. 6
    Multi-omics integration reveals convergent extracellular matrix remodelling and lipid metabolic reprogramming as central axes of adipocyte differentiation from mouse embryonic stem cells.

    Al-Sayegh M, Khalili M, Alzaabi M, Sultana M, Ali L, Ali M, El-Hadidi M. · 2026-06-02

    open access unreviewed
  7. 7
    The role of protein palmitoylation in disease pathogenesis and therapeutic innovation.

    Lin X, Xing J, Jia K, Liu S, Liu Y, Gu Y, Guo K, Yi J. · 2026-05-29

    open access unreviewed
  8. 8
    Overexpression of SLC44A4 suppresses ferroptosis and reduces lipid peroxidation <i>via</i> noncanonical NF-κB signaling in a NIK-dependent manner.

    Li T, Xu Y, Song W, Chang H, He J, Liu S, Liu Z, Xu Y, Yao Q, Song K. · 2026-05-25

    open access unreviewed
  9. 9
    Beyond spherical vesicles: morphological diversity of extracellular vesicles in health and disease.

    Velázquez-Cervantes MA, Fierro NA, Lozano-Hernández R, Carrero JC. · 2026-05-04

    open access unreviewed
  10. 10
    Metformin counteracts lipid accumulation and cell proliferation in hepatocellular carcinoma via regulating METTL3-mediated m<sup>6</sup>A methylation.

    Qi Y, Chen C, Dai Y, Wang Z, Liu X, Guo C, Wang M, Hu Z, Di H. · 2026-05-03

    unreviewed

External claims. These come from an index outside this database and are not checked against it. Treat them as leads.