beta-Ketoacyl-ACP synthase (KS) domain of FAS
Cofactors used
What it does, reaction by reaction
Fatty Acid Synthesis (De Novo Lipogenesis) Lipid Metabolism · Cytosol
Acetyl-KS + malonyl-ACP → acetoacetyl-ACP + CO2
Converts Acetyl-KS Malonyl-ACP into Acetoacetyl-ACP CO2
› Notes
The β-ketoacyl-ACP synthase (KS) domain catalyzes decarboxylative condensation, producing a four-carbon β-ketoacyl-ACP. No ATP is consumed in this condensation; decarboxylation of malonyl-ACP provides the thermodynamic drive. In subsequent rounds, the growing acyl chain replaces acetyl-KS.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
Nothing is fetched until you ask, so the page stays fast and the request is yours rather than automatic.
Europe PMC · ten most recent, newest first