alpha-Galactosidase A (GLA)
Clinical / pharmacological. Fabry disease (X-linked)
What it does, reaction by reaction
Sphingolipid Degradation (Lysosomal) Lipid Metabolism · Lysosome
Globotriaosylceramide (Gb3) -> lactosylceramide + galactose
Converts Globotriaosylceramide into Lactosylceramide Galactose
› Notes
X-linked deficiency causes Fabry disease (angiokeratomas, neuropathic pain, renal failure).
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
Europe PMC · fetched just now · sorted by publication date
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1
Calciphylaxis in chronic kidney disease: a systematic review of pathomechanisms and risk factors for calcific uremic arteriolopathy.
Søndergaard C, Nagarajah S, Shen J, Bladbjerg EM, Scholze A. · 2026-08-10
unreviewed -
2
Vitamin K status and vascular calcification biomarkers as determinants of carotid plaque in peritoneal dialysis: a prospective study.
Pamuk I, Cetin TE, Kindan BH, Akcay OF, Yildirim S, Sendur HN, Cerit MN, Gonen S, Akhan BM, Derici U, Guz G, … · 2026-06-22
open access unreviewed -
3
Cross-kingdom microbiome interactions along the gut-lung axis: immune-microecological coordination, shared mechanisms, and disease-context dependence in respiratory disorders.
Yu J, Meng J, Shi Z, Zou J, Lai Z. · 2026-06-21
open access unreviewed -
4
Immunological fitness of echinocandin-resistant <i>Nakaseomyces glabratus</i> (former <i>Candida glabrata</i>): The impact on the management of candidemia.
Basmaciyan L, Alvarez-Rueda N, Aldebert D, Sahnouni H, Garnaud C, Patarot D, Ducreux A, Bon F, Winckler P, Le… · 2026-05-19
open access unreviewed -
5
Integrated transcriptomic and proteomic analysis reveals inflammatory activation and blood-brain barrier disruption during meningitis-associated extraintestinal pathogenic <i>Escherichia coli</i> infection.
Li Z, Chen M, Du Y, Jia K, Lu Y, Yu X, Cao X, Peng L, Fang R. · 2026-05-11
open access unreviewed -
6
Elevated Metastasis-Associated lung adenocarcinoma transcript 1 (MALAT1) expression predicts coronary artery disease severity as a potential biomarker for risk stratification: a cross-sectional study.
Zheng J, Ludin AFM, Rajab NF, Farhana Jufri N. · 2026-04-30
cited 1× open access unreviewed -
7
Systematic metabolic engineering of <i>Escherichia coli</i> for high-level production of pseudouridine via pathway optimization and precursor enhancement.
Song J, Shen W, Xia Y, Zhou L, Zhou Y, Yang H, Chen X. · 2026-04-06
open access unreviewed -
8
Placental transport dysfunction in omega-3 and omega-6 fatty acid in patients with gestational diabetes mellitus.
Long W, Guo F, Yao J, Wei Q, Yin L, Xu J, Cao X. · 2026-04-20
open access unreviewed -
9
Development and validation of a self-management efficacy questionnaire for patients with Fabry disease in China.
Cao ML, Zou JH, Shi MY, Sun YH, Zhao DY, Li L, Jiang HK. · 2026-04-12
open access unreviewed -
10
Blood metabolic profiling associated with a short-term intensive training period in elite male water polo athletes: an exploratory metabolomics study.
Sun Z, Wang L. · 2026-03-18
open access unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.