unreviewed

alpha-Galactosidase A (GLA)

1 reactions · 1 pathways

Clinical / pharmacological. Fabry disease (X-linked)

What it does, reaction by reaction

1 reactions

Sphingolipid Degradation (Lysosomal) Lipid Metabolism · Lysosome

step 3 Irreversible/directional

Globotriaosylceramide (Gb3) -> lactosylceramide + galactose

Converts Globotriaosylceramide into Lactosylceramide Galactose

› Notes

X-linked deficiency causes Fabry disease (angiokeratomas, neuropathic pain, renal failure).

Showing all 1 reactions.

What accelerates and inhibits it

Regulation is pathway-specific, so each context is listed separately

0 entries

No regulation recorded for this enzyme in the source documents.

Recent literature

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Europe PMC · fetched just now · sorted by publication date

1
Characterization of two key cytochrome P450 enzymes in Isodon amethystoides and de novo production of 3α,15β-dihydroxy-ent-kaurene in yeast.
Chen Y, Song X, Wang Y, Han Y, Xia M, Yuan S, Ma Y, Wang J, Ma Q, Liu S, Su P, Huang L. · 2026-08-27

open access unreviewed
2
Engineering UiO-66 based architectures for electrochemical sensing: recent advances, analytical performance, challenges and future perspectives.
Ahmad K, Tripathi VK, Singh Gautam RK, Tripathi VM, Oh TH. · 2026-07-21

unreviewed
3
Ag-nanoparticle-decorated bimetallic MOF-derived hierarchical porous carbon nanorods with synergistic interfacial effect for performance zinc hybrid supercapacitors and sodium-ion batteries.
Kolachi UA, Andavar R, Kumar A, He Y, Raza A, Sun Y, Pan J. · 2026-08-19

unreviewed
4
Heterogeneous nuclear ribonucleoprotein A1 as a candidate associated with pulmonary vascular remodeling in pulmonary arterial hypertension.
Morimoto Y, Sato Y, Kato K, Yamamoto H, Suzuki K, Go K, Fukasawa Y, Ohashi N, Takahashi Y, Kato T. · 2026-08-31

open access unreviewed
5
AXL mediates influenza A virus entry and drives virus-induced inflammation.
Zuo W, He D, Wang D, Lyu C, Xu J, Zheng Y, Wang W, Li H, Tan W, Wang Z, Cao B. · 2026-09-09

open access unreviewed
6
Single-cell RNA sequencing reveals dysregulation of innate immune signaling in early-life respiratory syncytial virus infection with subsequent low-level cadmium exposure.
Jarrell ZR, Lee HY, Jeon J, Lim G, Lee CM, Kang SM, Chen Y, Jones DP, Go YM. · 2026-08-06

open access unreviewed
7
Clinical manifestations, diagnosis, and management of renal involvement in Fabry disease.
Guo W, Bi J, Ji P, Xie Y. · 2026-08-13

open access unreviewed
8
Calciphylaxis in chronic kidney disease: a systematic review of pathomechanisms and risk factors for calcific uremic arteriolopathy.
Søndergaard C, Nagarajah S, Shen J, Bladbjerg EM, Scholze A. · 2026-08-10

open access unreviewed
9
Tailored d-band states and hierarchical porosity in a multi-site high-entropy alloy unlock efficient H₂O dissociation-diffusion for water splitting under over-boiling conditions.
Andavar R, Yang M, Duan C, Kumar A, Sun Y, Pan J. · 2026-07-27

unreviewed
10
Biomaterials at the interface of bone-derived factors and inter-organ communication: Current evidence and future perspectives.
Ji L, Zhu F, Wang X, Wang J, Liu C. · 2026-07-13

open access unreviewed

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