Vitamin K epoxide reductase (VKORC1)
Clinical / pharmacological. Warfarin target; VKORC1 genotype drives dose variability
What it does, reaction by reaction
Vitamin K Cycle Cofactor & Vitamin Metabolism · ER membrane
Vitamin K 2,3-epoxide -> vitamin K quinone
Converts Vitamin K 2,3-epoxide into Vitamin K quinone
› Notes
The warfarin target. VKORC1 polymorphisms are a major determinant of warfarin dose requirement.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
Europe PMC · fetched just now · sorted by publication date
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1
Gene expression of anticoagulant rodenticide target genes (vkorc1 and vkorc1l1) in a non-target wildlife species: The eagle owl (Bubo bubo).
Spadetto L, Gómez-Ramírez P, García-Fernández AJ, León-Ortega M, Zamora-Marín JM, Zamora-López A, Calvo JF, R… · 2026-07-30
unreviewed -
2
The Effect of Dicloxacillin Administration on Pharmacokinetics of Narrow Therapeutic Window Drugs: Phenytoin and Warfarin.
Shaul C, Mujahed W, Idries I, Wanounou M, Bialer M, Caraco Y. · 2026-08-03
unreviewed -
3
Population Genomics Insights into Pharmacogenomic Differentiation Between East Asians and Europeans.
Chen S, Chen H, Xu S. · 2026-06-03
unreviewed -
4
Distribution and frequency of Vkorc1 polymorphisms in house mice and Norway rats in the northeastern United States.
Yu JJ, Toledo A, Kasprowicz AE, Phifer-Rixey MV, Pan X, Daramola B, Wang C. · 2026-04-21
unreviewed -
5
Optimizing Time in Therapeutic Range in Patients With HeartMate 3: Pharmacist-Led Anticoagulation Using Pharmacogenetics of Warfarin.
Gregor S, Merta D, Ivak P, Chrapkova K, Hojny M, Netuka I, Maly J. · 2026-07-09
unreviewed -
6
Ferulenol, a Prenylated Coumarin, Suppresses Collagen-Induced Platelet Activation via PLCγ2-Mediated cPLA2 Signaling in Humans.
Huang WC, Chang Y, Chang CY, Lee YX, Hsu CY, Hsia CW, Jayakumar T, Chang CC, Sheu JR. · 2026-06-01
unreviewed -
7
National genomic projects in Asia and Africa: a review.
Hanaya Alsuwaidi A, Mousa M, Olbrich M, Marzouka NAD, Wohlers I, Ibrahim S, Alsafar H. · 2026-06-30
unreviewed -
8
The N‑Glycoproteomic Landscape of the Lung in Monocrotaline-Induced Pulmonary Arterial Hypertension.
Lian G, Sagor MIH, Cai K, Chen Z, Xu C, Wang H, Zhuang W, Luo L, Xie L. · 2026-06-03
open access unreviewed -
9
VKORC1L1-mediated vitamin K recycling counters ferroptosis to promote endothelial repair.
Repges E, Aksoy A, Czogalla-Nitsche KJ, Zietzer A, Müller C, Oldenburg J, Zimmer S, Nickenig G, Tiyerili V, A… · 2026-06-19
open access unreviewed -
10
Association between the <i>VKORC1</i> rs8050894 CC genotype and undercarboxylated osteocalcin levels following vitamin K and D supplementation in Mexican Citizens with T2DM: A randomized clinical trial.
Salinas-Varela Y, Barajas-González MA, Martínez-López E, Llamas-Covarrubias IM, Lopez-Quintero A, Sánchez-Enr… · 2026-06-08
unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.