rate-limiting unreviewed
Vitamin K epoxide reductase (VKORC1)
1 reactions · 1 pathways
Clinical / pharmacological. Warfarin target; VKORC1 genotype drives dose variability
What it does, reaction by reaction
1 reactions
Vitamin K Cycle Cofactor & Vitamin Metabolism · ER membrane
step 2
Irreversible/directional rate-limiting
Vitamin K 2,3-epoxide -> vitamin K quinone
Converts Vitamin K 2,3-epoxide into Vitamin K quinone
› Notes
The warfarin target. VKORC1 polymorphisms are a major determinant of warfarin dose requirement.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
0 entries
No regulation recorded for this enzyme in the source documents.
Recent literature
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