Skip to content
MS
Sign in
unreviewed

Acyl-CoA synthetases

1 reactions · 1 pathways

Cofactors used

ATP CoA-SH · B5 (Pantothenic acid) PPi

What it does, reaction by reaction

1 reactions

Triacylglycerol Synthesis and Lipolysis Lipid Metabolism · Cytosol / ER

step 1 Irreversible

Fatty acid + CoA-SH + ATP → fatty acyl-CoA + AMP + PPi

Converts Fatty acid CoA-SH ATP into Fatty acyl-CoA AMP PPi

› Notes

Acyl-CoA synthetases activate each fatty acid destined for esterification. This effectively irreversible activation costs two ATP equivalents per acyl chain because ATP is cleaved to AMP and PPi.

Showing all 1 reactions.

What accelerates and inhibits it

Regulation is pathway-specific, so each context is listed separately

0 entries

No regulation recorded for this enzyme in the source documents.

Recent literature

Refresh

Europe PMC · fetched just now · sorted by publication date

  1. 1
    Structural and Mechanistic Basis of Dual Substrate Promiscuity in the Acyltransferase AntB Enables Late-Stage Diversification of Natural Products.

    Zheng M, Dai Y, Li X, Du Y, Zhu H, Li L, Wei G, Qu X. · 2026-09-30

    unreviewed
  2. 2
    Coupling Carbon-Source Transport with Antioxidant Biosynthesis in Yeast: Product Diversity and Engineering Strategies.

    Zhang MD, Yao YC, Zhao XQ, Li J, Zhang FL. · 2026-09-17

    open access unreviewed
  3. 3
    Role of mitochondria-associated ER membranes in lipid metabolism: implications for renal lipotoxicity.

    Gao Y, Shao M, Fang Y, Zeng J, Sun H. · 2026-09-01

    open access unreviewed
  4. 4
    Histone deacetylases in cancer metabolic reprogramming.

    Jeon YH, Seo H, Youn JW, Yoo J, Lee SW, Oh SY, Kwon SH. · 2026-09-02

    open access unreviewed
  5. 5
    In <i>Staphylococcus aureus</i>, MbcS is a refunctionalized acyl-CoA synthetase that confers a fitness advantage during intra-species competition.

    Ferreira MCdS, Stephens TG, Brinsmade SR. · 2026-08-27

    open access unreviewed
  6. 6
    Gut microbiota-derived short-chain fatty acids (SCFAs): immunomodulatory effects and therapeutic potential in infections.

    Yu J, Li W, Xu Y, Tang J. · 2026-06-10

    cited 1× open access unreviewed
  7. 7
    Remodeling of leaf lipidome during cold acclimation, de-acclimation, and re-acclimation influences frost tolerance of Festuca arundinacea.

    Górna J, Perlikowski D, Alseekh S, Rapacz M, Fernie AR, Wójcik-Jagła M, Kosmala A. · 2026-09-01

    open access unreviewed
  8. 8
    The impact of mineralocorticoid receptor antagonists on fat mass and fat metabolism.

    Afsar B, Afsar RE, Maddukuri G. · 2026-05-22

    open access unreviewed
  9. 9
    Triacylglycerol synthesis in microalgae under abiotic stress: an updated integrative review.

    Bhatnagar VS, Saldat M, Zienkiewicz A, Du ZY, Zienkiewicz K. · 2026-09-01

    open access unreviewed
  10. 10
    Integrated assessment of fatty acid metabolism and cellular energy status using HILIC-MS/MS

    · 2026-08-13

    open access unreviewed

External claims. These come from an index outside this database and are not checked against it. Treat them as leads.