Acyl-CoA synthetases
Cofactors used
What it does, reaction by reaction
Triacylglycerol Synthesis and Lipolysis Lipid Metabolism · Cytosol / ER
Fatty acid + CoA-SH + ATP → fatty acyl-CoA + AMP + PPi
Converts Fatty acid CoA-SH ATP into Fatty acyl-CoA AMP PPi
› Notes
Acyl-CoA synthetases activate each fatty acid destined for esterification. This effectively irreversible activation costs two ATP equivalents per acyl chain because ATP is cleaved to AMP and PPi.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
Europe PMC · fetched just now · sorted by publication date
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1
ACSL4 in Alzheimer's disease: Pathogenetic mechanisms and potential therapeutic targets.
Guo Y, Jiang Q, Gu Z, Cao H, Zuo C, Huang Y, Song Y, Chen X, Wang F. · 2025-09-18
cited 1× open access unreviewed -
2
Wheat MYB46-like Transcription Factor Stimulates Cuticular Wax Biosynthesis
· 2026-06-01
open access unreviewed -
3
Phospholipid remodeling as a key regulator of ferroptosis.
Shingaki T, Aoki J, Kono N. · 2026-06-25
unreviewed -
4
Lactate metabolism and lactylation in female reproductive diseases: From metabolic rewiring to biomarkers and translational therapeutics.
Qiao J, Xiao Y, Cheng Y, Xu W, Shu J, Li S. · 2026-06-01
open access unreviewed -
5
Metabolic Adaptation in Acute Ischemic Events: The Critical Role of Acyl-Coenzyme A Synthetase Family in Myocardial Infarction and Ischemic Stroke.
Zhou Y, Huang F, Yuan T, Zhang Z, Tipparaju S, Wu CY, Lee RH. · 2026-06-15
unreviewed -
6
Peroxisomal Lipid Metabolism as a Therapeutic Target in Leukemia.
Parfenova EN, Spagnuolo PA. · 2026-06-01
open access unreviewed -
7
Single-nucleus sequencing and spatial metabolomics analysis reveal the regulatory mechanism of ginkgolic acid biosynthesis in the episperm of <i>Ginkgo biloba</i>.
Feng Z, Yao Z, Wang Q, Zhang B, Wang H, Wang Y, Ai B, Zhang X, Jiang H, Xiao Y, Wang Y, Li M. · 2026-02-28
open access unreviewed -
8
The pyrrolidinamide antimalarial drug MMV367 rapidly clears blood-stage <i>Plasmodium falciparum</i> in healthy adults with experimental malaria.
Barber BE, Denhardt-Eriksson R, Guirou EA, Flynn J, Sahai N, Leelasena I, Mathison S, Moller C, Lim I, Evange… · 2026-06-10
unreviewed -
9
A Polarity-Sensitive Lipid Droplet Probe Reveals Aβ Species-Dependent Lipid Droplet Remodeling in Microglia.
Hu P, Guo S, Ren Y, Zhao R, Su L, Cheng J, Tian X. · 2026-06-09
unreviewed -
10
Chuangling Ye mitigates diabetic foot ulcer through suppressing keratinocyte ferroptosis via inhibiting ACSS2/ACSL4 axis.
Feng X, Yi N, Zhang C, Tang L, Yin X, Zhao Y, Zhu T, Zhu J, Feng Q, Chen W, Xia Y, Ma C. · 2026-06-08
open access unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.