unreviewed
Acyl-CoA synthetases
1 reactions · 1 pathways
Cofactors used
What it does, reaction by reaction
1 reactions
Triacylglycerol Synthesis and Lipolysis Lipid Metabolism · Cytosol / ER
step 1
Irreversible
Fatty acid + CoA-SH + ATP → fatty acyl-CoA + AMP + PPi
Converts Fatty acid CoA-SH ATP into Fatty acyl-CoA AMP PPi
› Notes
Acyl-CoA synthetases activate each fatty acid destined for esterification. This effectively irreversible activation costs two ATP equivalents per acyl chain because ATP is cleaved to AMP and PPi.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
0 entries
No regulation recorded for this enzyme in the source documents.
Recent literature
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