Uroporphyrinogen III synthase (UROS)
What it does, reaction by reaction
Heme Biosynthesis (Porphyrin Pathway) Amino Acid & Nitrogen Metabolism · Mitochondrion + cytosol
Hydroxymethylbilane → uroporphyrinogen III
Converts Hydroxymethylbilane into Uroporphyrinogen III
› Notes
Uroporphyrinogen III synthase (UROS) cyclizes and inverts ring D to form the asymmetric type III isomer. Without UROS, hydroxymethylbilane can spontaneously cyclize to uroporphyrinogen I, which cannot proceed efficiently to heme.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
Europe PMC · fetched just now · sorted by publication date
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1
FHL2 production enabled new insight into its flexibility and unexpected binding stoichiometry with β-catenin.
Logonder T, Prešern U, Gaber A. · 2026-08-20
open access unreviewed -
2
The extremophile Chlamydomonas acidophila PM01 survives high manganese contamination by restricting non-vacuolar intracellular content.
Santrač I, Dimitrijević M, Žižić M, Stanić M, Ćurić V, Bonanni V, Gianoncelli A, Aquilanti G, Stani C, Birard… · 2026-07-27
unreviewed -
3
Discovery of ALA-hydroxypyridinone hybrids: novel strategies for photodynamic therapy against superficial tumours.
Jiang X, Feng M, Niu X, Wang S, Sun Y, Chen W, Bai R. · 2026-07-08
open access unreviewed -
4
Proteomic Mendelian randomization and machine learning reveal causal plasma biomarkers in cardiorenal comorbidity.
Huang H, Liu W, Yan Y, Cao J, Wang J, Fang C. · 2026-06-16
open access unreviewed - 5
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6
Sequential TKI Treatment in Patients With Chronic Phase Chronic Myeloid Leukemia Resistant to Frontline Nilotinib or Dasatinib Therapy. A Real-Life Survey From the Italian Campus CML Network.
Gugliotta G, Annunziata M, Capodanno I, Rapezzi D, Attolico I, Caramella M, Vincelli ID, Rossi AR, Tiribelli … · 2026-07-24
unreviewed -
7
Evaluation of biotechnology approaches – Polyploidization and hybridization – For improvement of pikeperch (Sander lucioperca) larviculture and juvenile on-grow with special regard to morphological traits and gonadal development
Stanivuk J, Marinović Z, Kitanović N, Mozsár A, Káldy J, Várkonyi E, Molnár M, Müller T, Fazekas G, Kovács B,… · 2026-10-01
unreviewed -
8
Multiomic Profiling Links RDH12-Dependent Retinaldehyde Detoxification to Membrane Remodeling and Ferroptosis
· 2026-09-28
open access unreviewed - 9
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10
Antimicrobial potential of <i>Miscanthus</i> × <i>giganteus</i> extracts: linking <i>in vitro</i> and <i>in silico</i> activity with <i>in situ</i> efficacy in milk.
Robajac D, Stojković D, Gašić U, Zengin G, Cetiz MV, Petrović J. · 2026-09-25
open access unreviewed
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