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unreviewed

Uroporphyrinogen III synthase (UROS)

1 reactions · 1 pathways

What it does, reaction by reaction

1 reactions

Heme Biosynthesis (Porphyrin Pathway) Amino Acid & Nitrogen Metabolism · Mitochondrion + cytosol

step 4 Irreversible/directional

Hydroxymethylbilane → uroporphyrinogen III

Converts Hydroxymethylbilane into Uroporphyrinogen III

› Notes

Uroporphyrinogen III synthase (UROS) cyclizes and inverts ring D to form the asymmetric type III isomer. Without UROS, hydroxymethylbilane can spontaneously cyclize to uroporphyrinogen I, which cannot proceed efficiently to heme.

Showing all 1 reactions.

What accelerates and inhibits it

Regulation is pathway-specific, so each context is listed separately

0 entries

No regulation recorded for this enzyme in the source documents.

Recent literature

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Europe PMC · from cache · sorted by publication date

  1. 1
    Proteomic Mendelian randomization and machine learning reveal causal plasma biomarkers in cardiorenal comorbidity.

    Huang H, Liu W, Yan Y, Cao J, Wang J, Fang C. · 2026-06-16

    open access unreviewed
  2. 2
    Evaluation of biotechnology approaches – Polyploidization and hybridization – For improvement of pikeperch (Sander lucioperca) larviculture and juvenile on-grow with special regard to morphological traits and gonadal development

    Stanivuk J, Marinović Z, Kitanović N, Mozsár A, Káldy J, Várkonyi E, Molnár M, Müller T, Fazekas G, Kovács B,… · 2026-10-01

    unreviewed
  3. 3
    Epirus-yellow (EY): A dual naked-eye colorimetric and NIR fluorimetric chemosensor for the rapid, sensitive, and selective detection of Sn<sup>2</sup>.

    Tzeli D, Bika CG, Vrettos EI, Chinnarasu M, Diamantis DA, Chatzigiannis C, Kanaki Z, Javornik U, Essien NB, T… · 2026-06-09

    unreviewed
  4. 4
    In search of a Holy Grail - How to find the right dose for transcranial electrical stimulation.

    Konstantinović U, Filipović SR. · 2026-05-07

    unreviewed
  5. 5
    Phenolic-rich <i>Rubus caesius</i> roots from Turkmenistan: <i>in vitro</i> antioxidant, enzyme inhibition, antibacterial, and antifungal properties and <i>in silico</i> analysis.

    Korpayev S, Buluz EC, Kaya S, Glamočlija J, Popović N, Gašić U, Stojković D, Hamrayev H, Agamuradov M, Yagi S… · 2026-08-11

    unreviewed
  6. 6
    En-bloc Resection of Bladder Tumor Versus Conventional Transurethral Resection of Bladder Tumor: Long-term Oncological Outcomes from a Single-center Prospective Trial.

    Di Bello F, Diana P, Gallioli A, Territo A, Rodriguez-Faba Ó, Gaya JM, Huguet J, Belarmino AR, Lopez M, Avesa… · 2026-08-01

    unreviewed
  7. 7
    CoCryoViS: Collaborative online cryo-electron tomography visualization system.

    Mena O, Šmajdek U, Zhang W, Yu P, Klein T, Arold ST, Li S, Viola I, Bohak C, Bohak C. · 2026-08-01

    unreviewed
  8. 8
    In silico characterisation of a novel SARS-CoV-2 envelope protein inhibitor and in vitro validation against murine coronavirus.

    Kobe N, Dreisewerd L, Lukšič M, Pavlin M, Grošelj U, Podlipnik Č, Janc M, Lengar Ž, Mrak P, Tušek Žnidarič M,… · 2026-05-06

    unreviewed
  9. 9
    Elevated Estradiol and DHT Levels in the Prostatic Stroma as Key Drivers of Benign Prostatic Hyperplasia Pathogenesis.

    Pejčić T, Jadranin M, Đurašević S, Kalaba M, Dojčinović B, Zeković M, Bumbaširević U, Jovanović D, Laketić D,… · 2026-07-29

    unreviewed
  10. 10
    Comparative Phytochemical Characterization and Bioactivity Profiling of Serbian <i>Ajuga</i> Species from Different Localities: Antioxidant, Antityrosinase, Antimicrobial and Anti-Pyocyanin Activities.

    Džamić AM, Matejić JS, Mileski KS, Žarković LD, Marković MS, Dragićević AV, Gašić UM, Mišić DM, Ćirić AD. · 2026-07-27

    unreviewed

External claims. These come from an index outside this database and are not checked against it. Treat them as leads.