unreviewed
Uroporphyrinogen III synthase (UROS)
1 reactions · 1 pathways
What it does, reaction by reaction
1 reactions
Heme Biosynthesis (Porphyrin Pathway) Amino Acid & Nitrogen Metabolism · Mitochondrion + cytosol
step 4
Irreversible/directional
Hydroxymethylbilane → uroporphyrinogen III
Converts Hydroxymethylbilane into Uroporphyrinogen III
› Notes
Uroporphyrinogen III synthase (UROS) cyclizes and inverts ring D to form the asymmetric type III isomer. Without UROS, hydroxymethylbilane can spontaneously cyclize to uroporphyrinogen I, which cannot proceed efficiently to heme.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
0 entries
No regulation recorded for this enzyme in the source documents.
Recent literature
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