UDP-glucose dehydrogenase (UGDH)
Cofactors used
Clinical / pharmacological. Supplies UDP-glucuronate for conjugation and GAG synthesis
What it does, reaction by reaction
Uronic Acid Pathway Carbohydrate Metabolism · Cytosol
UDP-glucose + 2 NAD+ + H2O -> UDP-glucuronate + 2 NADH + 2 H+
Converts UDP-glucose NAD+ H2O into UDP-glucuronate NADH H+
› Notes
Committed step; supplies UDP-glucuronate for glucuronidation (bilirubin, drugs, steroids) and for glycosaminoglycan/proteoglycan synthesis.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
Europe PMC · fetched just now · sorted by publication date
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1
Enhanced lactose utilization from milk enriched in Uridine-5'-monophosphate drives hepatic energy storage in young mammals.
Gao LM, Liu L, Yang XD, Long CM, Wu X. · 2026-06-01
open access unreviewed -
2
Targeting UXS1-Dependent Glucuronate Detoxification Potentiates Metformin's Anti-Tumor Efficacy in Lung Adenocarcinoma.
Sui Q, Chen Z, Shan G, Hu Z, Jin X, Liang J, Yi Y, Yin J, Shi H, Jiang X, Xi J, Lin Z, Zhan C, Sun F, Jiang W. · 2026-05-10
unreviewed -
3
Proteome-wide Mendelian randomization identifies causal plasma proteins in frontotemporal dementia.
Yao Y, Zou Q, Chen K. · 2026-07-25
unreviewed -
4
Probe-Based Chemical Proteomics Identifies UDP-Glucose 6-Dehydrogenase as a Potential Cannabidiol-Interacting Protein.
Wang X, Chu F, Zhou S, Chen B, Zou S, Fei Q, Ren R, Su M, Di B. · 2026-06-23
unreviewed -
5
The emerging role of lactate in skeletal homeostasis and disorders: Integrated mechanisms and translational opportunities.
Zong B, Yu F, Li S, Sun P. · 2026-06-06
open access unreviewed -
6
Two-Step <i>Vibrio parahaemolyticus</i> Challenge Reveals Transcriptional Reprogramming of Trained Immunity in Shrimp Hemocytes.
Li Z, Li S, Lv X, Li F. · 2026-06-18
open access unreviewed -
7
Awns Enhance the Thousand Seed Weight of <i>Elymus nutans</i> Griseb. by Regulating Carbohydrate Contents and Gene Expression.
Qiu Y, Lu H, Zhao Y, Tang L, Zhang F, Zhang R, Xie W. · 2026-06-01
open access unreviewed -
8
The signaling and regulatory functions of dying cells and cell corpses.
Zhang G, Liu J, Li W, Wang B, Feng H, Cui T, Pan T, Chen D, Xiong Y. · 2026-06-08
open access unreviewed -
9
C-terminally clustered UGDH hypomorphic variants reveal subtle mechanisms of cellular and developmental disruption.
Harwood H, Zimmer BM, Utz AR, Venema M, Allego E, Skirboll SS, Harding A, Enders JR, Grantham-Hill S, Elmslie… · 2026-04-28
unreviewed -
10
Biomimetic villi-crypt scaffold-on-chip with tunable mechanical properties for intestinal epithelium modeling.
Zavagna L, Casanova MR, Pierantoni L, Carvalho MR, Silva-Correia J, Macchi T, Troisi F, Giovannoni R, Reis RL… · 2026-04-20
open access unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.