UDP-glucose dehydrogenase (UGDH)
Cofactors used
Clinical / pharmacological. Supplies UDP-glucuronate for conjugation and GAG synthesis
What it does, reaction by reaction
Uronic Acid Pathway Carbohydrate Metabolism · Cytosol
UDP-glucose + 2 NAD+ + H2O -> UDP-glucuronate + 2 NADH + 2 H+
Converts UDP-glucose NAD+ H2O into UDP-glucuronate NADH H+
› Notes
Committed step; supplies UDP-glucuronate for glucuronidation (bilirubin, drugs, steroids) and for glycosaminoglycan/proteoglycan synthesis.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
Europe PMC · fetched just now · sorted by publication date
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1
Integrated metabolomic and transcriptomic analysis reveal the flavor formation mechanism during oat grain development.
Qin Y, Wang T, Liu H, Guo Y, Yang X, Yang Y, Shagdarsuren D, Han B. · 2026-06-22
open access unreviewed -
2
Enhanced lactose utilization from milk enriched in Uridine-5'-monophosphate drives hepatic energy storage in young mammals.
Gao LM, Liu L, Yang XD, Long CM, Wu X. · 2026-06-01
open access unreviewed -
3
Mesenchymal stem cell-derived extracellular vesicle treatment of induced pluripotent stem cell-derived motor neurons with different amyotrophic lateral sclerosis genetic backgrounds.
Varderidou-Minasian S, Jakobs CE, Pasteuning-Vuhman S, Gal L, Timmers A, Altelaar M, Lorenowicz MJ, Pasterkam… · 2026-02-05
open access unreviewed -
4
Hidden causal inference delineates dynamic lncRNA regulation in autism spectrum disorder.
Zhang J, Wei X, Zhao C, Hu Z, Fan S. · 2026-09-01
open access unreviewed -
5
The Tol-Pal System Promotes Pseudoiodinine Production by Enhancing Bacterial Growth in <i>Pseudomonas mosselii</i>.
Yang R, Du X, Zhang H, Yang J, Huang Z, Xu N, Zou L, Chen G. · 2026-09-17
open access unreviewed -
6
Population-Associated Molecular Variation in Histologically Normal Breast Tissue Is Associated with Distinct Baseline Transcriptional States.
Hulsy WD, Salazar K, Chalkia D, Chavez Y, Zhao Y, Halkia G, Razorenova OV, Nikolaidis N. · 2026-09-17
open access unreviewed -
7
Lactylation Remodels Tumorigenesis, Immune Microenvironment, and Therapeutic Response.
Liu Y, Zhou Y, Xue H, Xu R, Liu Y. · 2026-09-10
open access unreviewed -
8
Estrogen promotes tumor phenotypes in ER+ and ER- breast cancer through UGDH-GPR30.
Price MJ, Nguyen AD, Strawser CH, Trivedi T, Baeta CC, Lavau C, Byemerwa JK, Mukherjee D, Wardell SE, Artham … · 2026-09-08
open access unreviewed -
9
Noncoding RNA encoded peptides in tumors from discovery to mechanism and clinical translation.
Zhou D, Li H, Yang J, He M, Yang L, Jian L. · 2026-08-24
open access unreviewed -
10
Shotgun proteomic analysis of quail liver under feed deprivation and low-energy diet conditions.
Khalifeh DM, Gulyás G, Knop R, Reda GK, Kalló G, Szabó C, Csösz É, Czeglédi L. · 2026-08-11
open access unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.