UDP-glucose dehydrogenase (UGDH)
Cofactors used
Clinical / pharmacological. Supplies UDP-glucuronate for conjugation and GAG synthesis
What it does, reaction by reaction
Uronic Acid Pathway Carbohydrate Metabolism · Cytosol
UDP-glucose + 2 NAD+ + H2O -> UDP-glucuronate + 2 NADH + 2 H+
Converts UDP-glucose NAD+ H2O into UDP-glucuronate NADH H+
› Notes
Committed step; supplies UDP-glucuronate for glucuronidation (bilirubin, drugs, steroids) and for glycosaminoglycan/proteoglycan synthesis.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
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