unreviewed

UDP-galactose 4-epimerase (GALE)

1 reactions · 1 pathways

Cofactors used

NAD+ · B3 (Niacin)

What it does, reaction by reaction

1 reactions

Galactose Metabolism Carbohydrate Metabolism · Cytosol

step 5 Reversible

UDP-galactose ↔ UDP-glucose

Converts UDP-galactose into UDP-glucose

› Notes

UDP-galactose 4-epimerase (GALE) requires tightly bound NAD+ as a catalytic cofactor and reversibly epimerizes carbon 4. It regenerates UDP-glucose for step 4 and also supports UDP-galactose production for glycosylation reactions.

Showing all 1 reactions.

What accelerates and inhibits it

Regulation is pathway-specific, so each context is listed separately

1 entries

Galactose Metabolism

Listed there as: UDP-galactose 4-epimerase

Accelerated by

UDP-galactose/UDP-glucose demand

Inhibited by

Severe NAD+ cofactor or enzyme deficiency

Hormonal control

No dominant acute hormonal control; flux reflects glycosylation and galactose load

Recent literature

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