Tyrosine aminotransferase (TAT)
Cofactors used
What it does, reaction by reaction
Amino Acid Catabolism Overview (glucogenic vs. ketogenic amino acids; brief overview of branched-chain amino acid catabolism and phenylalanine/tyrosine catabolism as representative examples) Amino Acid & Nitrogen Metabolism · Cytosol + mitochondrion
L-tyrosine + α-ketoglutarate ⇌ 4-hydroxyphenylpyruvate + glutamate
Converts Tyrosine Alpha-ketoglutarate into 4-Hydroxyphenylpyruvate Glutamate
› Notes
Tyrosine aminotransferase catalyzes this PLP-dependent, reversible reaction. Its activity is induced in liver by glucocorticoids during catabolic states.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
Amino Acid Catabolism Overview (glucogenic vs. ketogenic amino acids; brief overview of branched-chain amino acid catabolism and phenylalanine/tyrosine catabolism as representative examples)
Listed there as: Tyrosine aminotransferase
Tyrosine availability
Product accumulation
Glucocorticoids induce hepatic enzyme expression; insulin has opposing fed-state effects
Recent literature
Europe PMC · fetched just now · sorted by publication date
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1
Discovery of functional compounds from dimorphic edible <i>Ophiocordyceps sinensis</i> fungus in host haemolymph.
Sun T, Yang Y, Xie J, Rao Z, Han R, Cao L. · 2026-04-17
open access unreviewed -
2
A clinically defined and xeno-free hydrogel system for regenerative medicine.
Ong J, Gibbons G, Lim YS, Zhou L, Zhao J, Justin AW, Cammarata F, Rajarethinam R, Limegrover C, Sinha S, Laka… · 2026-05-04
open access unreviewed -
3
Scoparone enhances the stability of TAT protein by inhibiting the Ubiquitin-Proteasome pathway, regulates mitochondrial damage against chronic alcoholic liver disease.
Wang C, Sun Y, Yang L, Ren J, Fang H, Sun Y, Yan G, Kong L, Han Y, Wang X, Sun H. · 2026-04-25
unreviewed -
4
Functional effects of rosmarinic acid on gut health and epigenetic regulation in antibiotic-free poultry diets.
Abd El-Hack ME, Ashour EA, Khafaga AF, Khaleel HK, Kamal M, Taha AE, Alfifi AE, Al-Rasheed M, Khan MMH. · 2026-04-16
open access unreviewed -
5
Integrated multi-omics analysis reveals the molecular mechanism underlying poplar 107 rootstock-mediated regulation of <i>Populus tomentosa</i> scion growth.
Wu J, Ren Y, Wang C, Yang K, Jiang M, Wang J, Yang M. · 2026-03-11
open access unreviewed -
6
FOXA2 in islet biology: Orchestrating pancreatic development and glucose homeostasis.
Elsayed AK, Manzoor Y, Abdelalim EM. · 2025-12-09
open access unreviewed -
7
Role of exogenous treatments of phenylalanine and tyrosine in the mechanism of yeast-secreted protein PgASP enhancing blue mold resistance in citrus fruits.
Li S, Chen O, Li H, Ming J, Zeng K. · 2026-04-03
unreviewed -
8
Telomere-Associated Proliferative Capacity in Expandable Porcine Hepatocyte-like Progenitor Cells.
Ock SA, Kim Y, Ullah I, Kim YI, Lee R, Oh KB, Hwang S, Lee J. · 2026-06-18
open access unreviewed -
9
Constitutive upregulation of tyrosine metabolism is associated with pyriproxyfen resistance in eggs of the Asian corn borer, Ostrinia furnacalis.
Rao C, Qin Z, He W, Guo H, Liu K, Xia W, Su J. · 2026-05-05
unreviewed -
10
Association analysis and in silico functional predictions of RMDN2 variants in chickens.
Li A, Liao Y, Luo Y, Zhu R, Zhang C, Wang X, Ma M, Sun L, Qu L, Shen M. · 2026-03-11
open access unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.