Tyrosine aminotransferase (TAT)
Cofactors used
What it does, reaction by reaction
Amino Acid Catabolism Overview (glucogenic vs. ketogenic amino acids; brief overview of branched-chain amino acid catabolism and phenylalanine/tyrosine catabolism as representative examples) Amino Acid & Nitrogen Metabolism · Cytosol + mitochondrion
L-tyrosine + α-ketoglutarate ⇌ 4-hydroxyphenylpyruvate + glutamate
Converts Tyrosine Alpha-ketoglutarate into 4-Hydroxyphenylpyruvate Glutamate
› Notes
Tyrosine aminotransferase catalyzes this PLP-dependent, reversible reaction. Its activity is induced in liver by glucocorticoids during catabolic states.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
Amino Acid Catabolism Overview (glucogenic vs. ketogenic amino acids; brief overview of branched-chain amino acid catabolism and phenylalanine/tyrosine catabolism as representative examples)
Listed there as: Tyrosine aminotransferase
Tyrosine availability
Product accumulation
Glucocorticoids induce hepatic enzyme expression; insulin has opposing fed-state effects
Recent literature
Europe PMC · fetched just now · sorted by publication date
-
1
Discovery of functional compounds from dimorphic edible <i>Ophiocordyceps sinensis</i> fungus in host haemolymph.
Sun T, Yang Y, Xie J, Rao Z, Han R, Cao L. · 2026-04-17
open access unreviewed -
2
A noncanonical function of the tyrosine degradation enzyme FAH drives CDK4/6 inhibitor resistance in breast cancer.
Högström J, Doh HM, Kump A, Petrova B, Wang P, Lee JD, Koivula K, Kozlova N, Cruz KA, Hong SM, Perea C, Garg … · 2026-09-30
open access unreviewed -
3
Enhancement of rosmarinic acid biosynthesis in Ocimum basilicum L. via melatonin-loaded nanoparticles: insights into enzymatic activity and gene expression.
Gad RA, Hathout TA, El Khallal SM, Fahmy AH, Hussein GM, Elshamy MT. · 2026-09-02
open access unreviewed -
4
Unveiling the genetic blueprint of verbascoside biosynthesis in <i>Olea europaea</i>: an integrative metabolomics, genetics and transcriptomics approach.
Pizzi S, Mariotti R, Pinosio S, Cattivelli A, Tagliazucchi D, Bashir MA, Cruciani L, Mousavi S. · 2026-04-17
cited 1× open access unreviewed -
5
A clinically defined and xeno-free hydrogel system for regenerative medicine.
Ong J, Gibbons G, Lim YS, Zhou L, Zhao J, Justin AW, Cammarata F, Rajarethinam R, Limegrover C, Sinha S, Laka… · 2026-05-04
open access unreviewed -
6
Scoparone enhances the stability of TAT protein by inhibiting the Ubiquitin-Proteasome pathway, regulates mitochondrial damage against chronic alcoholic liver disease.
Wang C, Sun Y, Yang L, Ren J, Fang H, Sun Y, Yan G, Kong L, Han Y, Wang X, Sun H. · 2026-04-25
unreviewed -
7
Unraveling the Multifaceted Role of TRIM21 in Virus-Triggered Innate Immunity and Diseases.
Lan S, Wang Y, Fu Y, Yang S, Shen Q, Wang X, Zhang W, Wang D, Ji L. · 2026-08-26
open access unreviewed -
8
CHFR drives gastric cancer stemness and hepatic metastasis by suppressing ITCH-mediated ubiquitination and degradation of OCT4.
Dai M, Wang J, Xu Q, Shao Y, Wang H, Wu X, Pan J, Ye B. · 2026-08-19
open access unreviewed -
9
Plant <i>In Vitro</i> Production of Phenolic Bioactives: Molecular Regulation, Functional Equivalence and Translational Challenges.
Kujawska A, Król P, Laban O, Karczyński P. · 2026-08-04
open access unreviewed -
10
Functional effects of rosmarinic acid on gut health and epigenetic regulation in antibiotic-free poultry diets.
Abd El-Hack ME, Ashour EA, Khafaga AF, Khaleel HK, Kamal M, Taha AE, Alfifi AE, Al-Rasheed M, Khan MMH. · 2026-04-16
open access unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.