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unreviewed

Triose phosphate isomerase

4 reactions · 4 pathways

What it does, reaction by reaction

4 reactions

Fructose Metabolism (Fructolysis) Carbohydrate Metabolism · Cytosol

step 4 Reversible

Dihydroxyacetone phosphate ↔ glyceraldehyde-3-phosphate

Converts Dihydroxyacetone phosphate into Glyceraldehyde-3-phosphate

› Notes

Triose phosphate isomerase reversibly interconverts the products of fructolysis as needed for downstream glycolysis or gluconeogenesis. No additional ATP or redox cofactor is used.

Gluconeogenesis Carbohydrate Metabolism · Cytosol + mitochondrion + ER

step 9 Reversible

Glyceraldehyde-3-phosphate ↔ dihydroxyacetone phosphate

Converts Glyceraldehyde-3-phosphate into Dihydroxyacetone phosphate

› Notes

Triose phosphate isomerase reversibly interconverts the trioses. One glyceraldehyde-3-phosphate remains unchanged, while the other is isomerized for condensation.

Glycolysis Carbohydrate Metabolism · Cytosol

step 5 Reversible

Dihydroxyacetone phosphate → glyceraldehyde-3-phosphate

Converts Dihydroxyacetone phosphate into Glyceraldehyde-3-phosphate

› Notes

Triose phosphate isomerase reversibly interconverts the two trioses through an enediol intermediate. Only glyceraldehyde-3-phosphate continues directly through the payoff reactions, so one glucose yields two glyceraldehyde-3-phosphate molecules from this point onward.

Anaerobic Glycolysis / Lactic Acid Fermentation Energy Metabolism & Cellular Respiration · Cytosol

step 5 Reversible

Dihydroxyacetone phosphate ⇌ glyceraldehyde-3-phosphate

Converts Dihydroxyacetone phosphate into Glyceraldehyde-3-phosphate

› Notes

Required cofactor: none. This reversible step ensures that both three-carbon products proceed as glyceraldehyde-3-phosphate; from this point, steps 6–10 occur twice per glucose.

Showing all 4 reactions.

What accelerates and inhibits it

Regulation is pathway-specific, so each context is listed separately

0 entries

No regulation recorded for this enzyme in the source documents.

Recent literature

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Europe PMC · fetched just now · sorted by publication date

  1. 1
    Systematic evaluation of the DNA repair machinery facilitated the development of efficient genome editing tools for the red yeast <i>Rhodotorula toruloides</i>.

    Chen Q, Lyu L, Wang S, Zhao ZK. · 2026-08-06

    open access unreviewed
  2. 2
    Investigation of geographical differences among Giardia duodenalis assemblage B populations using diverse haplotypes identified by cloning of PCR amplicons.

    Mizuno T, Asih PBS, Lacante SA, Hendarto J, Matsumura T, Bi X, Matey EJ, Syafruddin D, Songok EM, Ichimura H,… · 2026-08-22

    unreviewed
  3. 3
    Clostridioides difficile in West Africa: a systematic review of the limited evidence and key knowledge gaps.

    Usuanlele MT, Kabali C, Mbuagbaw L, Loeb M, Mertz D. · 2026-08-18

    open access unreviewed
  4. 4
    TWIST2-dependent transcriptional activation of TPI1 mediates TGF-β1-driven fibroblast activation in pulmonary fibrosis.

    Chen J, Li Y, Fu K, Qiu H, Cui Y, Chen Z, Yang J, Shao C, Zeng W, Zhou X, Xing Y, Lv X, Tong X, Zhao J, Li C. · 2026-08-22

    unreviewed
  5. 5
    Gut protist diversity in Eurasian beavers (<i>Castor fiber</i>) revealed by metabarcoding.

    Kandaurova E, Novák J, Náhlovský J, Perglerová A, Jewell JB, Vorel A, Munclinger P, Tůmová P, Hampl V. · 2026-08-03

    open access unreviewed
  6. 6
    A HEK293T-derived explainable CatBoost signature for estimating HCoV-OC43 viral burden from host transcriptomes.

    Jeon H, Lee C. · 2026-08-10

    unreviewed
  7. 7
    Stress-induced remodeling of membrane-bound organelles in budding yeast.

    Sheng P, Sun M, Wang X, Bai L, Cao H, Li D. · 2026-07-28

    open access unreviewed
  8. 8
    Qdr3 Coordinates cellular homeostasis, mitochondrial remodeling, and virulence in <i>Candidozyma auris</i> (<i>Candida auris</i>).

    Munhoz da Rocha IF, Ennis CL, Romagnoli BA, Schemiko K, Rossi SA, da Costa AT, de Oliveira HC, Nobile CJ, Alv… · 2026-07-15

    open access unreviewed
  9. 9
    Thraustochytrid PUFA synthase ER domains form a stable heterodimer.

    Lofeudo N, Moncalian G. · 2026-06-10

    open access unreviewed
  10. 10
    Detection of zoonotic protozoa in raccoons (<i>Procyon lotor</i>) from aquaculture zones in Saxony (Germany): One health perspective.

    Lindhorst ZTL, Unterköfler MS, Solarczyk P, Striese M, Jeschke D, Striese E, Ansorge H, Fuehrer HP, Heddergot… · 2026-06-13

    open access unreviewed

External claims. These come from an index outside this database and are not checked against it. Treat them as leads.