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unreviewed

Triose phosphate isomerase

4 reactions · 4 pathways

What it does, reaction by reaction

4 reactions

Fructose Metabolism (Fructolysis) Carbohydrate Metabolism · Cytosol

step 4 Reversible

Dihydroxyacetone phosphate ↔ glyceraldehyde-3-phosphate

Converts Dihydroxyacetone phosphate into Glyceraldehyde-3-phosphate

› Notes

Triose phosphate isomerase reversibly interconverts the products of fructolysis as needed for downstream glycolysis or gluconeogenesis. No additional ATP or redox cofactor is used.

Gluconeogenesis Carbohydrate Metabolism · Cytosol + mitochondrion + ER

step 9 Reversible

Glyceraldehyde-3-phosphate ↔ dihydroxyacetone phosphate

Converts Glyceraldehyde-3-phosphate into Dihydroxyacetone phosphate

› Notes

Triose phosphate isomerase reversibly interconverts the trioses. One glyceraldehyde-3-phosphate remains unchanged, while the other is isomerized for condensation.

Glycolysis Carbohydrate Metabolism · Cytosol

step 5 Reversible

Dihydroxyacetone phosphate → glyceraldehyde-3-phosphate

Converts Dihydroxyacetone phosphate into Glyceraldehyde-3-phosphate

› Notes

Triose phosphate isomerase reversibly interconverts the two trioses through an enediol intermediate. Only glyceraldehyde-3-phosphate continues directly through the payoff reactions, so one glucose yields two glyceraldehyde-3-phosphate molecules from this point onward.

Anaerobic Glycolysis / Lactic Acid Fermentation Energy Metabolism & Cellular Respiration · Cytosol

step 5 Reversible

Dihydroxyacetone phosphate ⇌ glyceraldehyde-3-phosphate

Converts Dihydroxyacetone phosphate into Glyceraldehyde-3-phosphate

› Notes

Required cofactor: none. This reversible step ensures that both three-carbon products proceed as glyceraldehyde-3-phosphate; from this point, steps 6–10 occur twice per glucose.

Showing all 4 reactions.

What accelerates and inhibits it

Regulation is pathway-specific, so each context is listed separately

0 entries

No regulation recorded for this enzyme in the source documents.

Recent literature

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Europe PMC · from cache · sorted by publication date

  1. 1
    Detection of zoonotic protozoa in raccoons (<i>Procyon lotor</i>) from aquaculture zones in Saxony (Germany): One health perspective.

    Lindhorst ZTL, Unterköfler MS, Solarczyk P, Striese M, Jeschke D, Striese E, Ansorge H, Fuehrer HP, Heddergot… · 2026-06-13

    open access unreviewed
  2. 2
    The RNA binding protein ZFP36L2 displays tissue-selective mRNA targeting in mice.

    Stephenson GS, Fleifel D, Cook JG, Laederach A, Ramos SBV. · 2026-06-21

    open access unreviewed
  3. 3
    Engineering of fructose-6-phosphate aldolase for one-carbon conversion to mannitol in a designed biotransformation system.

    Wang D, Dong Q, Chen P, Zeng Y, Liu Y, Sun Y, Tan J, Yang J. · 2026-06-05

    open access unreviewed
  4. 4
    TIM-1 promotes infection with mosquito cell-derived alphaviruses through virion-associated phospholipids.

    Yoo JE, de Bruin ACM, Reßin H, Paužuolis M, Liu L, Moosmann A, Becker M, Lasswitz L, Groß R, Gerold G. · 2026-06-09

    open access unreviewed
  5. 5
    Beyond <i>difficile</i>: three novel toxin B-producing <i>Clostridioides</i> species from human patients with diarrhea.

    Aguilar D, Riedel T, Maaß S, Trautwein-Schult A, Neumann-Schaal M, Kirstein S, Schober I, Bunk B, Acuña-Amado… · 2026-05-29

    open access unreviewed
  6. 6
    Iterative evolution of <i>Saccharomyces cerevisiae</i> enhances recombinant protease secretion.

    Liu X, Lian M, Zeng J, Zheng L, Zhao M, Huang M. · 2026-04-25

    open access unreviewed
  7. 7
    DRP1 depletion protects NK cells from hypoxia-induced dysfunction.

    Verhezen T, Van Den Eynde A, Verstraelen P, Gehrcken L, Palmiotto G, Lau HW, De Vos WH, Van Der Heijden S, Br… · 2026-02-18

    open access unreviewed
  8. 8
    Giardiavirus rewires host translation and glycolytic metabolism to support its replication in <i>Giardia duodenalis</i>.

    Li L, Cao L, Zhong C, Zhang N, Li X, Wang X, Guo Y, Yu Y, Li J, Zhang X, Le Y, Yuan J, Gong P. · 2025-12-24

    cited 3× open access unreviewed
  9. 9
    Co-transplantation of pancreatic islets with adipose-derived mesenchymal stem cells in vascularized kidney ECM scaffolds to restore type 1 diabetes mellitus.

    Choi M, Shanto PC, Fahad MAA, Bae SH, Lee BT. · 2026-06-04

    open access unreviewed
  10. 10
    Bioengineered titanium implants functionalized with aptamer-valproic acid conjugates orchestrate macrophage programming and mesenchymal stem cell homing for improved osseointegration.

    Sun D, Zhou Q, Guo X, Shi H, Wang X, Li X, Zheng Z, Zhong L, Cao S, Shan R, Su Z, Ma C, Zhao L. · 2026-06-06

    open access unreviewed

External claims. These come from an index outside this database and are not checked against it. Treat them as leads.