unreviewed
Tissue-specific synthases (PGE synthase; prostacyclin synthase; thromboxane synthase)
1 reactions · 1 pathways
What it does, reaction by reaction
1 reactions
Eicosanoid Synthesis Lipid Metabolism · Cytosol / ER / nuclear membrane
step 3
Irreversible/directional
PGH2 -> PGE2 / PGD2 / PGF2alpha / PGI2 / TXA2
Converts PGH2 into PGE2 / PGD2 / PGF2alpha / PGI2 / TXA2
› Notes
Endothelium favours PGI2 (vasodilator, antiaggregatory); platelets favour TXA2 (vasoconstrictor, proaggregatory) - the basis of low-dose aspirin cardioprotection.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
0 entries
No regulation recorded for this enzyme in the source documents.
Recent literature
No articles returned.