unreviewed
TCA-cycle enzyme set (downstream oxidation)
1 reactions · 1 pathways
What it does, reaction by reaction
1 reactions
Ketolysis (Ketone Body Utilization) Lipid Metabolism · Mitochondrial matrix
step 4
Irreversible/directional
2 acetyl-CoA → 4 CO2 through two TCA-cycle turns
Converts Acetyl-CoA
› Notes
Citrate synthase, isocitrate dehydrogenase, α-ketoglutarate dehydrogenase, succinyl-CoA synthetase, succinate dehydrogenase, malate dehydrogenase, and associated reactions oxidize the acetyl groups. This downstream oxidation yields reducing equivalents and GTP, but the SCOT reaction has displaced one GTP equivalent per acetoacetate activated.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
0 entries
No regulation recorded for this enzyme in the source documents.
Recent literature
No articles returned.