What it does, reaction by reaction
Phase II - Conjugation Xenobiotic & Drug Metabolism · Cytosol + ER
Substrate + PAPS -> sulfate conjugate + PAP
› Notes
High-affinity but low-capacity; saturates before glucuronidation.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
Europe PMC · fetched just now · sorted by publication date
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1
Evaluation of a pantoprazole and 4-desmethylpantoprazole-sulfate metabolic ratio as a novel CYP2C19 phenotyping method.
Müller JP, Belov VN, Yamoune S, Miller B, Hasoumi M, Tupiec J, Laurentius T, Bollheimer LC, Stingl JC, Just K… · 2026-05-31
open access unreviewed -
2
Quercetin as a Therapeutic Agent for Oral Cancer: Current Evidence and Future Directions.
Sun H, Wang H, Guo S. · 2025-11-14
cited 1× unreviewed -
3
Genetic Variation in <i>NR1I2</i> and Palbociclib Safety and Prognosis in Advanced Breast Cancer: An Exploratory Multicenter Study.
Arqueros C, Andrés M, Servitja S, Giner J, Tibau A, Borrell M, Martinez-Recio S, Barnadas A, Salazar J. · 2026-09-18
open access unreviewed -
4
Functional and Mechanistic Studies of the <i>EST</i> Gene in the Gonads of <i>Chlamys farreri</i>.
Li Y, Cui W, Liu X. · 2026-09-08
open access unreviewed -
5
In vitro formation kinetics of two 2,5-dimethylfuran phase-I metabolites: cis-3-hexene-2,5-dione and 5-methylfurfuryl alcohol.
Appel J, Kulosa C, Becker N, Stegmüller S, Sadzik S, Richling E. · 2026-05-20
open access unreviewed -
6
Microbial levan potentiates hepatic retention and antitumor activity of a PEGylated benzimidazole-curcumin nanocomplex through TLR2-FXR/FGF15-associated immunometabolic remodeling in experimental liver cancer.
Shawky H, Ibrahim NE, Amer MN, Al-Ashmawy AAK, Hammam OA, Fayed DB, Maghraby AS. · 2026-08-12
open access unreviewed -
7
Hydroxyhydroquinone as a novel modulator of mitochondrial metabolism with potential to restore CoQ10 homeostasis.
Dos Santos PR, Rastegar J, Roesch-Ely M. · 2026-08-07
open access unreviewed -
8
Toward internal threshold for toxicological concern: in vitro hepatocyte metabolism testing of 207 chemicals using cryopreserved suspended hepatocytes for physiologically based pharmacokinetic modeling.
Ellison CA, Api AM, Becker RA, Black S, Joshi K, Selechnik D. · 2026-08-01
open access unreviewed -
9
Comparative Metabolomics Reveals the Production of Sulfated Metabolites by Human Gut Bacteria.
D'Agostino GD, Kim CH, Park J, Zhang Y, Amer B, Franzosa EA, Bird SS, Huttenhower C, Huh JR, Devlin AS. · 2026-08-01
open access unreviewed -
10
The Evolution of Precision Anti-Doping From UGT2B17 Polymorphism Insights to Integrated Detection Frameworks.
Cheng J, Li Z, Zheng T, Ma R, Xiang X, Deng X, Liu B. · 2026-05-22
unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.