Sphingomyelin synthase (SGMS1/2)
What it does, reaction by reaction
Sphingolipid Synthesis Lipid Metabolism · ER + Golgi
Ceramide + phosphatidylcholine -> sphingomyelin + diacylglycerol
Converts Ceramide Phosphatidylcholine into Sphingomyelin Diacylglycerol
› Notes
Occurs in the Golgi; sphingomyelin is a major myelin and plasma-membrane lipid.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
Europe PMC · fetched just now · sorted by publication date
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1
Sphingolipid Remodeling and Extracellular Vesicle Signatures Reflect Disease Severity in Facioscapulohumeral Dystrophy Driven by Mitochondrial Dysfunction and Endoplasmic Reticulum Stress.
Moriggi M, Ruggiero L, Torretta E, Zoppi D, Arosio B, Fiorillo C, Nigro V, Capitanio D, Gelfi C. · 2026-09-14
open access unreviewed -
2
Circular RNA <i>circDNAJC5</i> Regulates Ultrafine Particle-Disrupted Microglial Lipid Metabolism via the Sphingolipid Signaling Pathway.
Zeng HX, Li G, Zeng QG, Zhang Q, Liu L, Zeng XW. · 2026-02-23
open access unreviewed -
3
Acid ceramidase overactivity drives ceramide loss, leading to atopic dry skin and Th2-skewed immune polarization.
Takada M, Sashikawa-Kimura M, Ohno Y, Hossain MR, Xie X, Iwabuchi K, Komine M, Ohtsuki M, Imokawa G. · 2026-03-24
open access unreviewed -
4
Comprehensive bioinformatics analysis targeting sphingosine-related genes in head and neck cancer.
Hamada M, Yura Y, Uzawa N. · 2026-05-21
open access unreviewed -
5
Ceramide metabolism in oxidative and glycolytic muscle: Significance for lipid-induced insulin resistance.
Eurén T, Flockhart M, Strmeň T, Zhou X, Horwath O, Apró W, Blackwood SJ, Tischer D, Moberg M, Steneberg P, Ed… · 2026-02-16
open access unreviewed -
6
Functional lipid analysis via index-based lipidomics profile: a new computational module in LipidOne.
Alabed HBR, Frongia Mancini D, Pergola M, Romani L, Martino S, Koulman A, Pellegrino RM. · 2026-02-01
cited 2× open access unreviewed -
7
Aromatase Inhibitor Therapy Is Associated with Distinct Plasma Lipidomic Profiles in Postmenopausal Breast Cancer Patients.
Arsic A, Kvasnicka A, Friedecky D, Ivanovic N, Milosevic M, Vucic V. · 2026-02-17
open access unreviewed -
8
Disruption of Hepatic Insulin Signaling Causes Phospholipid Dysregulation in Mice.
Pan Q, Pan M, Ai W, Yang W, Jiang W, Han X, Guo S. · 2026-02-01
open access unreviewed -
9
Targeting Sphingolipids in Breast Cancer: From Tumor Biology to Therapeutic Strategies.
Kim MH, Huh B, Park JW, Park WJ. · 2026-01-19
cited 1× open access unreviewed -
10
The small GTPase ARF6 regulates sphingolipid homeostasis and supports proliferation in acute myeloid leukemia.
Zhao HG, Cruz-Rodriguez N, Johnson KC, Pomicter AD, Bates B, Bateman B, Haferlach T, Gu T, Ahmann J, Yan D, L… · 2025-07-10
cited 3× open access unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.