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Sphingomyelin synthase (SGMS1/2)

1 reactions · 1 pathways

What it does, reaction by reaction

1 reactions

Sphingolipid Synthesis Lipid Metabolism · ER + Golgi

step 5 Irreversible/directional

Ceramide + phosphatidylcholine -> sphingomyelin + diacylglycerol

Converts Ceramide Phosphatidylcholine into Sphingomyelin Diacylglycerol

› Notes

Occurs in the Golgi; sphingomyelin is a major myelin and plasma-membrane lipid.

Showing all 1 reactions.

What accelerates and inhibits it

Regulation is pathway-specific, so each context is listed separately

0 entries

No regulation recorded for this enzyme in the source documents.

Recent literature

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Europe PMC · from cache · sorted by publication date

  1. 1
    Acid ceramidase overactivity drives ceramide loss, leading to atopic dry skin and Th2-skewed immune polarization.

    Takada M, Sashikawa-Kimura M, Ohno Y, Hossain MR, Xie X, Iwabuchi K, Komine M, Ohtsuki M, Imokawa G. · 2026-03-24

    open access unreviewed
  2. 2
    Ceramide metabolism in oxidative and glycolytic muscle: Significance for lipid-induced insulin resistance.

    Eurén T, Flockhart M, Strmeň T, Zhou X, Horwath O, Apró W, Blackwood SJ, Tischer D, Moberg M, Steneberg P, Ed… · 2026-02-16

    open access unreviewed
  3. 3
    Functional lipid analysis via index-based lipidomics profile: a new computational module in LipidOne.

    Alabed HBR, Frongia Mancini D, Pergola M, Romani L, Martino S, Koulman A, Pellegrino RM. · 2026-02-01

    open access unreviewed
  4. 4
    Aromatase Inhibitor Therapy Is Associated with Distinct Plasma Lipidomic Profiles in Postmenopausal Breast Cancer Patients

    Arsic A, Kvasnicka A, Friedecky D, Ivanovic N, Milosevic M, Vucic V. · 2026-02-01

    open access unreviewed
  5. 5
    Disruption of Hepatic Insulin Signaling Causes Phospholipid Dysregulation in Mice.

    Pan Q, Pan M, Ai W, Yang W, Jiang W, Han X, Guo S. · 2026-02-01

    open access unreviewed
  6. 6
    Targeting Sphingolipids in Breast Cancer: From Tumor Biology to Therapeutic Strategies.

    Kim MH, Huh B, Park JW, Park WJ. · 2026-01-19

    cited 1× open access unreviewed
  7. 7
    The small GTPase ARF6 regulates sphingolipid homeostasis and supports proliferation in acute myeloid leukemia.

    Zhao HG, Cruz-Rodriguez N, Johnson KC, Pomicter AD, Bates B, Bateman B, Haferlach T, Gu T, Ahmann J, Yan D, L… · 2025-07-10

    cited 3× open access unreviewed
  8. 8
    Protective mechanisms against Alzheimer's disease in APOE3-Christchurch homozygous astrocytes.

    Tian X, Rivera EK, Hwang I, Nikitina AA, Smith JA, Cho YJ, Sala-Jarque J, DuBose A, Andriola C, Gollan-Myers … · 2025-09-01

    cited 5× open access unreviewed
  9. 9
    Unveiling the role of lipid metabolism in haemorrhagic disorders: genetic insights and therapeutic perspectives.

    Wei J, Yang Z, Wu X, Zheng N, Wu D. · 2025-05-31

    cited 1× open access unreviewed
  10. 10
    Supplementation with Lentil (<i>Lens culinaris</i>) Hull Soluble Dietary Fiber Ameliorates Sodium Dextran Sulfate-Induced Colitis and Behavioral Deficits via the Gut-Brain Axis.

    Chen D, Bi X, Feng Q, Sun Y. · 2025-03-03

    cited 1× open access unreviewed

External claims. These come from an index outside this database and are not checked against it. Treat them as leads.