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unreviewed

Sorbitol dehydrogenase (SORD)

1 reactions · 1 pathways

Cofactors used

NAD+ · B3 (Niacin)

Clinical / pharmacological. Low in lens/retina/nerve, so sorbitol is trapped in diabetes

What it does, reaction by reaction

1 reactions

Sorbitol / Polyol Pathway Carbohydrate Metabolism · Cytosol

step 2 Reversible

Sorbitol + NAD+ -> fructose + NADH + H+

Converts Sorbitol NAD+ into Fructose NADH H+

› Notes

Absent or low in lens, retina, kidney and Schwann cells, so sorbitol is trapped there; osmotic damage underlies diabetic cataract, retinopathy and neuropathy. Seminal vesicles use this route to make fructose for sperm.

Showing all 1 reactions.

What accelerates and inhibits it

Regulation is pathway-specific, so each context is listed separately

0 entries

No regulation recorded for this enzyme in the source documents.

Recent literature

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Europe PMC · fetched just now · sorted by publication date

  1. 1
    White matter microstructural alterations in obstructive sleep apnea assessed by time-dependent diffusion MRI.

    Taoka T, Ito R, Iwamoto K, Miyata S, Nakamichi R, Nakane T, Iima M, Fujishiro H, Ikeda M, Ichikawa K, Kamiunt… · 2026-04-16

    unreviewed
  2. 2
    Metabolic reprogramming in polyol pathway contributes to anti-inflammatory effect of glucosamine salts on synovial fibroblasts.

    Okada J, Nakano R, Kitanaka N, Kitanaka T, Namba S, Nakano M, Naruke A, Nunomura J, Suwabe Y, Konno T, Tohi T… · 2026-07-01

    unreviewed
  3. 3
    Sorbose metabolism promotes fitness and virulence in <i>Escherichia coli</i>.

    Deng X, Shen C, Chen L, Sun D, Qiu T, Zhao Z, Li T, Zhang G, Wu J, Wang J, Tian G-B, Xu L, Yan B, Zhong L-L. · 2026-06-15

    unreviewed
  4. 4
    In-Depth Plasma Proteomics Identifies SNCA as a Discriminating Biomarker of PDAC.

    Yu J, Luo W, Zhang J, Qin B, Wang X, Yang G, Hou W, Li C, Liu F, Sun S, Liu X, Ying W. · 2026-06-01

    unreviewed
  5. 5
    Biphasic Dose–Response and Mechanism Analysis of Vanillic Acid from Larix gmelinii on Neofusicoccum laricinum

    Chen X, Zhang R, Zhang Z, Wang H, Zhang Y, Li D, Wang F. · 2026-06-01

    open access unreviewed
  6. 6
    Effects of trehalose, melatonin and lipid mixtures on bull sperm parameters and gene expressions during cryopreservation.

    Ağır V, Bucak MN, Garip M, Sarı ME, İnanç ME. · 2026-06-10

    unreviewed
  7. 7
    Correction to: Expanding the phenotype of SORD mutation.

    · 2026-06-02

    unreviewed
  8. 8
    <i>The stack overflow recommendations dataset (SORD)</i> - A large-scale curated dataset of recommendations related stack overflow questions, answers and comments.

    Fatima A, Maqbool O. · 2026-05-06

    open access unreviewed
  9. 9
    Integrated multi-omics data and machine learning approaches to decipher the molecular network and gene signatures of renal cell carcinoma induced by aristolochic acid.

    Zhang F, Han S, Pan D, Gao L, Song W. · 2026-04-18

    unreviewed
  10. 10
    Measurement of Red Blood Cell Sorbitol Dehydrogenase Activity for Fast Screening of SORD-Related Neuropathies.

    Moro N, Francois S, Grondin C, Ben Salem S, Rajagopal S, Aykut D, Arezki L, Larramendi JM, Berquet C, Willems… · 2026-06-01

    unreviewed

External claims. These come from an index outside this database and are not checked against it. Treat them as leads.