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unreviewed

Sorbitol dehydrogenase (SORD)

1 reactions · 1 pathways

Cofactors used

NAD+ · B3 (Niacin)

Clinical / pharmacological. Low in lens/retina/nerve, so sorbitol is trapped in diabetes

What it does, reaction by reaction

1 reactions

Sorbitol / Polyol Pathway Carbohydrate Metabolism · Cytosol

step 2 Reversible

Sorbitol + NAD+ -> fructose + NADH + H+

Converts Sorbitol NAD+ into Fructose NADH H+

› Notes

Absent or low in lens, retina, kidney and Schwann cells, so sorbitol is trapped there; osmotic damage underlies diabetic cataract, retinopathy and neuropathy. Seminal vesicles use this route to make fructose for sperm.

Showing all 1 reactions.

What accelerates and inhibits it

Regulation is pathway-specific, so each context is listed separately

0 entries

No regulation recorded for this enzyme in the source documents.

Recent literature

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Europe PMC · fetched just now · sorted by publication date

  1. 1
    Spatiotemporal dynamics of the host-tumor metabolic interface: Implications for precision nutritional oncology.

    Li M, Huang C, Yu S. · 2026-07-02

    open access unreviewed
  2. 2
    Proteomics of highly post-translationally modified proteins in kidney tubulointerstitium

    · 2026-10-02

    open access unreviewed
  3. 3
    Dietary Fructose and Early-Onset Colorectal Cancer: Metabolic, Microbial, and Translational Perspectives.

    Tangyingyong S, Abu-Fares H, Susiriwatananont T. · 2026-09-14

    open access unreviewed
  4. 4
    Accelerated Pancreatic Volume Loss as a Potential Pre-Diagnostic Imaging Biomarker for Pancreatic Cancer Risk Enrichment: An AI-Assisted Volumetric Study.

    Nakahodo J, Ujita W, Sadato D, Fukumura Y, Aoki Y, Kikuyama M, Horiguchi SI, Suzuki M, Chiba K, Tabata H, Hos… · 2026-09-21

    open access unreviewed
  5. 5
    Cataract GWAS meta-analysis and multi-omics Mendelian randomisation inform disease mechanisms and candidate target prioritisation.

    Hong X, Zhang L, Zuber V, Zhuang Z, Cronjé HT, Burgess S, Gill D. · 2026-09-22

    open access unreviewed
  6. 6
    TargetQC: A targeted quality control framework for clinical genomic testing.

    Lan F, Wang Y, Lu Y, Wu B, Wang X, Li C, Liu B, Dong X. · 2026-08-31

    open access unreviewed
  7. 7
    Guidelines for Genetic Testing of Peripheral Nerve Disorders.

    Saporta MA. · 2026-09-09

    unreviewed
  8. 8
    Unexpected Conduction Blocks in <i>SORD</i>-Related Distal Motor Neuropathy: A Case Report.

    Bucur AA, Rodolico G, Tessa A, Santorelli FM, Sperti M, Leccese D, Maturo M, Matà S. · 2026-09-01

    open access unreviewed
  9. 9
    Spectrum of Hereditary Neuropathies in Adult Patients From Serbia.

    Vukojevic M, Marjanovic A, Ivanovic V, Pesovic J, Kosac A, Candayan A, Jankovic M, Savic-Pavicevic D, Jordano… · 2026-09-01

    unreviewed
  10. 10
    The KIF6-RBP Complex Orchestrates mRNA Transport Required for Sperm Flagellar Assembly.

    Xie C, Yi S, Lin X, Zhang S, Wang W, Yuan S, Meng L, Li Y, Tan C, Wei C, Yu Y, Liang Y, Zhang H, Hu L, Lu G, … · 2026-06-25

    open access unreviewed

External claims. These come from an index outside this database and are not checked against it. Treat them as leads.