Aconitase (aconitate hydratase)
Cofactors used
What it does, reaction by reaction
Citric Acid Cycle (TCA / Krebs Cycle) Energy Metabolism & Cellular Respiration · Mitochondrial matrix
Citrate ⇌ cis-aconitate ⇌ isocitrate
Converts Citrate into cis-Aconitate
› Notes
Required cofactor: a [4Fe–4S] iron-sulfur cluster that assists substrate binding and catalysis; it is not consumed. This reversible step relocates the hydroxyl group, converting a tertiary alcohol into the secondary alcohol needed for oxidation.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
Europe PMC · fetched just now · sorted by publication date
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1
Different treatments regulate starch degradation, ethylene biosynthesis, and energy metabolism involved in the preparation and shelf life of ready-to-eat kiwifruit.
Liu X, Tang S, Ji N, Lei J, Chen C, Zheng P, Liu B, Wang R. · 2026-06-23
open access unreviewed -
2
Active ROP2 triggers leaf senescence and orchestrates the growth-senescence trade-off under nitrogen starvation.
Zhang T, Ye H, Zhang Y, Wang J, Wang J, Lixiang S, Lin Z, Xiong Y, Liu Y. · 2026-06-13
open access unreviewed -
3
The role of copper and cuproptosis in digestive system cancers: novel therapeutic strategies and mechanistic insights.
Xu G, Yao N, Cheng R, Yang L, Han F, Qu J, Li W. · 2026-03-16
cited 1× open access unreviewed -
4
Metabolomic profiling of neat uterine luminal fluid in cows: local enrichment and nutritional modulation.
Sagheer M, Hoorn QA, Maldonado MB, Schalich KM, Ashrafi N, A Mimi R, Graham SF, Selvaraj V, Hansen PJ. · 2026-01-07
cited 4× open access unreviewed -
5
The Maintenance of Dysmyelinated Small-Diameter Axons by 14-3-3s in the Central Nervous System.
Yamada N, Saito H, Takahashi R, Fujisato M, Hosoda Y, Sasaki B, Yamada M, Abe S, Hayashi C, Yoshimoto A, Ohka… · 2026-11-01
open access unreviewed -
6
Metal-phenolic nanocapsules enable a self-amplifying cuproptosis-STING cascade for synergistic cancer immunotherapy.
Yu J, Zhang R, Sun Z, Sekhar KPC, Sun W, Yang X, Gao Z, Cui J, Yu D. · 2026-06-24
open access unreviewed -
7
Root‐sourced 1‐aminocyclopropane‐1‐carboxylic acid modulates development and adaptive responses to salinity in tomato
Martín‐Rodríguez J, Martínez‐Melgarejo P, Guillamón J, Prudencio Á, Guerrero J, Larriba E, Pérez‐Pérez J, Olm… · 2026-10-01
open access unreviewed -
8
Multi-omics profiling of circulating proteins and metabolites in persistent atrial fibrillation: VDAC1 identified as a candidate circulating protein.
Wang J, Chen X, Zhang Z, Gui C. · 2026-08-31
open access unreviewed -
9
A single-cell study of transcription and RNA splicing in MDD and ALC.
Chen G, Zhu X, Chu C, Qin Z, Chen Y. · 2026-08-27
unreviewed -
10
Reprogramming the tumor microenvironment with oxygen-driven nanomotors for cuproptosis-enhanced immunotherapy.
Gu X, Shen S, He Y, Xue C, Zhang M, Fan Y, Xu Z, Zhang L, Xie Y, Wang Z, Li L, Lu J, Shi Q. · 2026-08-11
open access unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.