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unreviewed

Aconitase (aconitate hydratase)

1 reactions · 1 pathways

Cofactors used

Fe-S cluster · Iron

What it does, reaction by reaction

1 reactions

Citric Acid Cycle (TCA / Krebs Cycle) Energy Metabolism & Cellular Respiration · Mitochondrial matrix

step 2 Reversible

Citrate ⇌ cis-aconitate ⇌ isocitrate

Converts Citrate into cis-Aconitate

› Notes

Required cofactor: a [4Fe–4S] iron-sulfur cluster that assists substrate binding and catalysis; it is not consumed. This reversible step relocates the hydroxyl group, converting a tertiary alcohol into the secondary alcohol needed for oxidation.

Showing all 1 reactions.

What accelerates and inhibits it

Regulation is pathway-specific, so each context is listed separately

0 entries

No regulation recorded for this enzyme in the source documents.

Recent literature

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Europe PMC · fetched just now · sorted by publication date

  1. 1
    Active ROP2 triggers leaf senescence and orchestrates the growth-senescence trade-off under nitrogen starvation.

    Zhang T, Ye H, Zhang Y, Wang J, Wang J, Lixiang S, Lin Z, Xiong Y, Liu Y. · 2026-06-13

    open access unreviewed
  2. 2
    The role of copper and cuproptosis in digestive system cancers: novel therapeutic strategies and mechanistic insights.

    Xu G, Yao N, Cheng R, Yang L, Han F, Qu J, Li W. · 2026-03-16

    open access unreviewed
  3. 3
    Metabolomic profiling of neat uterine luminal fluid in cows: local enrichment and nutritional modulation.

    Sagheer M, Hoorn QA, Maldonado MB, Schalich KM, Ashrafi N, A Mimi R, Graham SF, Selvaraj V, Hansen PJ. · 2026-01-07

    cited 3× open access unreviewed
  4. 4
    Diagnostic Yield and Clinical Impact of Comprehensive WES/WGS Testing Beyond Common Genetic Causes in Hereditary Optic Atrophy.

    Johannesen KM, Grønskov K, Kessel L, Holstein SLV, Møller LB, Andersen MKG, Khinchi MS, Hamann S, Wegener M, … · 2026-06-27

    unreviewed
  5. 5
    Beyond proteostasis: LONP1 as an immunometabolic checkpoint in health and disease.

    Xie L, Wu LH, Ni XC, Zhang JN. · 2026-06-16

    unreviewed
  6. 6
    Nitric oxide-driven Warburg reprogramming at the NOS2-COX2 axis: An integrative engine of cancer hallmarks.

    Coutinho LL, Palmieri EM, Ridnour LA, Cheng RYS, Heinz WF, Anderson SK, Billiar TR, Chang J, Lockett SJ, Rang… · 2026-06-02

    open access unreviewed
  7. 7
    Integrated molecular mechanisms of salinity response in Apostichopus japonicus: focus on miRNA-driven core pathways and target gene regulation.

    Chen J, Zhao Y, Li N, Wang H, Wu X, Wang B, Wei X, Chang Y, Tian Y. · 2026-08-10

    unreviewed
  8. 8
    Identifying key pathways and genes in the progression of wooden breast across multiple broiler lines using weighted gene co-expression network analysis.

    Yuan H, Xu K, Xu Q, Liu S, Wang S. · 2026-01-07

    unreviewed
  9. 9
    A Biomimetic Copper-Caffeic Acid Nanozyme Activates Cuproptosis and Pyroptosis by Mimicking the Neutrophil Enzymatic Cascade.

    Lu Y, Li Y, Yan H, Sun X, Li X, Fang Y, Zhang S, Tian J, Wang X, Luo C, Qiu W, Qi W. · 2026-07-02

    unreviewed
  10. 10
    Nuclear-specific reductive carboxylation of alpha-ketoglutarate fuels histone acetylation to induce chromatin accessibility and gene activation.

    Sawant Dessai A, Elhalawany NA, Dai T, Jacobi JJ, Prechtl C, Dimeck AN, Morton SR, Long MD, Singh PK, Putluri… · 2026-07-01

    unreviewed

External claims. These come from an index outside this database and are not checked against it. Treat them as leads.