Aconitase (aconitate hydratase)
Cofactors used
What it does, reaction by reaction
Citric Acid Cycle (TCA / Krebs Cycle) Energy Metabolism & Cellular Respiration · Mitochondrial matrix
Citrate ⇌ cis-aconitate ⇌ isocitrate
Converts Citrate into cis-Aconitate
› Notes
Required cofactor: a [4Fe–4S] iron-sulfur cluster that assists substrate binding and catalysis; it is not consumed. This reversible step relocates the hydroxyl group, converting a tertiary alcohol into the secondary alcohol needed for oxidation.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
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