Serine palmitoyltransferase (SPT)
Cofactors used
Clinical / pharmacological. Rate-limiting for sphingolipid synthesis; SPTLC1 mutations cause HSAN type I
What it does, reaction by reaction
Sphingolipid Synthesis Lipid Metabolism · ER + Golgi
Serine + palmitoyl-CoA -> 3-ketosphinganine + CO2 + CoA-SH
Converts Serine Palmitoyl-CoA into 3-Ketosphinganine CO2 CoA-SH
› Notes
Rate-limiting and committed step; located on the ER.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
Europe PMC · fetched just now · sorted by publication date
-
1
Gut microbiota metabolic reprogramming drives the development of metabolic diseases in the host.
Wang Y, Huang B, Wei X, Guan Y, Li L, Zheng Y, Sun W. · 2026-03-14
cited 10× open access unreviewed -
2
Infectious spleen and kidney necrosis virus promotes replication organelle formation and sphingolipid biosynthesis to facilitate viral replication.
Xiao W, Fu X, Zhu Y, Liu Q, Lin Q, Liang H, Luo X, Niu Y, Ma B, Li N. · 2026-08-11
unreviewed -
3
Sphingolipid homeostasis and dysregulation in liver function and disease.
Lan J, Pan Z, Dong W, Wang J, Zhang C, Zhang Y, Wu Y, Jin J. · 2026-04-24
open access unreviewed -
4
Characterization of novel and recurrent <i>SPTLC2</i> variants in childhood-onset amyotrophic lateral sclerosis: Insights into sphingolipid dysregulation.
Fu X, Gable K, Gupta SD, Zhang K, Jia B, Wang W, Yang X, Wang L, Ge L, Bönnemann CG, Dunn TM, Xiong H. · 2025-08-23
cited 3× unreviewed -
5
Ceramide-Driven Mechanisms in Pulmonary Fibrosis.
Li Z, Li Y, Mao N, Gao X, Xu H, Cai W, Li T. · 2026-06-16
unreviewed -
6
Unraveling the complex role of intestinal microbiota in drug permeability: Insights from N-acetylcysteine.
Tian C, He Z. · 2026-05-22
open access unreviewed -
7
Proteome Responses to Acute Inhibition of De Novo Sphingolipid Synthesis Suggest Cancer Combination Therapies.
Luu TTT, Zhang D, Bheemanapally K, Zaman M, Wu Z, Liu Y, Wu X, Kim HE, Zheng L, Ogretmen B, Peng J, Du G. · 2026-06-02
open access unreviewed -
8
Cardiac Lipid Metabolism: Cells, Metabolites, and Rhythms.
Goldberg IJ, Young ME, Schulze PC, Drosatos K. · 2026-06-04
cited 1× unreviewed -
9
Geraniol Exerts Cytotoxic Effects in Red Cells Through Ca<sup>2+</sup> Elevation and Membrane Hyperpolarization: Attenuating Effects of COX/CK1α/Rac1 GTPase Inhibition.
Alfhili MA, Alruwaili SH, Alsughayyir J. · 2026-05-12
open access unreviewed -
10
Liver-derived ceramides link metabolism to tissue wasting in cancer cachexia.
Huang K, Perrimon N, Goncalves MD. · 2026-05-15
open access unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.