Serine palmitoyltransferase (SPT)
Cofactors used
Clinical / pharmacological. Rate-limiting for sphingolipid synthesis; SPTLC1 mutations cause HSAN type I
What it does, reaction by reaction
Sphingolipid Synthesis Lipid Metabolism · ER + Golgi
Serine + palmitoyl-CoA -> 3-ketosphinganine + CO2 + CoA-SH
Converts Serine Palmitoyl-CoA into 3-Ketosphinganine CO2 CoA-SH
› Notes
Rate-limiting and committed step; located on the ER.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
Europe PMC · fetched just now · sorted by publication date
-
1
Deletion of the T1D risk gene <i>Ormdl3</i> in β-cells does not impact disease progression.
Ou Q, Jones EF, Currey K, Engin F. · 2026-09-05
open access unreviewed -
2
Non-ergosterol lipid remodeling governs amphotericin B susceptibility via TOR-calcineurin signaling in <i>Candida glabrata</i>.
Kumar M, Kumari S, Wasi M, Ali B, Kumar P, Sharma G, Singh A, da Silva Dantas A, Gow NAR, Gaur NA, Prasad R. · 2026-08-26
open access unreviewed -
3
Gut microbiota metabolic reprogramming drives the development of metabolic diseases in the host.
Wang Y, Huang B, Wei X, Guan Y, Li L, Zheng Y, Sun W. · 2026-03-14
cited 40× open access unreviewed -
4
Infectious spleen and kidney necrosis virus promotes replication organelle formation and sphingolipid biosynthesis to facilitate viral replication.
Xiao W, Fu X, Zhu Y, Liu Q, Lin Q, Liang H, Luo X, Niu Y, Ma B, Li N. · 2026-08-11
unreviewed -
5
Hypertensive stretch regulates endothelial cell inflammation and apoptosis through ceramide metabolism.
Pietromicca-Victor JG, Chitkara S, Muñoz E, Manzar ZA, Bharathi Rajan AP, Bieberich E, Atilla-Gokcumen GE, Al… · 2026-09-02
unreviewed -
6
The role of sphingolipids in major depressive disorder and associated cognitive impairment: interactions with monoaminergic signaling, neuroinflammation, and neurogenesis.
Hoertel N, Mühle C, Müller CP, Chaieb H, Scheer V, Fayad M, Sánchez-Rico M, Limosin F, Kornhuber J. · 2026-05-13
cited 1× open access unreviewed -
7
Serine palmitoyltransferase (SPT) inhibition in SPTSSA-related complex hereditary spastic paraplegia.
Gong Y, Thompson R, Glover AM, Gable K, Gupta SD, Golovanov N, Tassinari J, Casey N, Wishart BD, Townsend EL,… · 2026-09-29
unreviewed -
8
Circulating Amino Acid Profiles in Adults with Abnormal Body Mass Index: Associations with Triglycerides, HDL Cholesterol, LDL Cholesterol, and Total Cholesterol in an Exploratory Cross-Sectional Metabolomic Pilot Study.
Jaskulak M, Rybakowska I, Gregorczyk M, Antoniak-Pietrynczak K, Jabłońska P, Zorena K. · 2026-09-09
open access unreviewed -
9
Sphingolipid Remodeling and Extracellular Vesicle Signatures Reflect Disease Severity in Facioscapulohumeral Dystrophy Driven by Mitochondrial Dysfunction and Endoplasmic Reticulum Stress.
Moriggi M, Ruggiero L, Torretta E, Zoppi D, Arosio B, Fiorillo C, Nigro V, Capitanio D, Gelfi C. · 2026-09-14
open access unreviewed -
10
Roles of inflammation and metabolic dysfunction in cardiovascular diseases: molecular mechanisms and therapeutic targets.
Pan Y, Li WH, Zhang W, Ma WJ, Sun H. · 2026-09-24
open access unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.