SR-BI (selective uptake) / CETP (cholesteryl ester transfer protein)
What it does, reaction by reaction
Lipoprotein Metabolism (Exogenous and Endogenous Pathways: chylomicrons, VLDL, LDL, HDL) Lipid Metabolism · Intestine, liver, plasma, capillary endothelium
HDL cholesteryl ester → liver directly or to apoB particles indirectly
Converts Cholesteryl ester into Cholesterol
› Notes
HDL delivers cholesteryl esters directly to liver/steroidogenic tissues through scavenger receptor class B type I (SR-BI) selective uptake. Alternatively, cholesteryl ester transfer protein (CETP) exchanges HDL cholesteryl ester for TAG from VLDL/IDL/LDL; the apoB-containing particles can then be cleared by liver. Hepatic lipase and endothelial lipase remodel HDL and influence HDL particle size and turnover.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
No articles returned.