Acid sphingomyelinase (SMPD1)
Clinical / pharmacological. Niemann-Pick disease types A and B
What it does, reaction by reaction
Sphingolipid Degradation (Lysosomal) Lipid Metabolism · Lysosome
Sphingomyelin + H2O -> ceramide + phosphocholine
Converts Sphingomyelin H2O into Ceramide Phosphocholine
› Notes
Deficiency causes Niemann-Pick disease types A/B (cherry-red macula, hepatosplenomegaly, foam cells).
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
Europe PMC · fetched just now · sorted by publication date
-
1
Clinical manifestations, diagnosis, and management of renal involvement in Fabry disease.
Guo W, Bi J, Ji P, Xie Y. · 2026-08-13
open access unreviewed -
2
<i>Lactobacillus johnsonii</i> mediates the protective effects of pristimerin against ulcerative colitis and concomitant liver injury through remodeling hepatic lipid metabolism via LXRα-SCD1 axis.
Cheng Y, Wu ZE, Huang R, Li Q, Yan D, Chen Y, Zhu W, Li F. · 2026-07-17
open access unreviewed -
3
Neonatal genetic sequencing as a first-tier option: a real-world clinical implementation study in Northern China.
Mu J, Sun M, Li Y, Li P, Zou H. · 2026-07-09
open access unreviewed -
4
Non-immune hydrops fetalis (NIHF): diagnostic evaluation and lessons learned from a case series.
Al Hassan J, Yared G, El Hajjar C, Dahrouj M, Massaad C, El Moghrabi A, Ghazal K. · 2026-06-03
open access unreviewed -
5
Cerebrospinal Fluid Neuromarker Levels in Patients With Schizophrenia and Healthy Control Participants: A Proximity Extension Assay Study.
Hidese S, Hattori K, Enokida T, Tatsumi M, Matsumura R, Kunugi H. · 2026-08-11
open access unreviewed -
6
The lipidomic architecture of the mouse brain.
Fusar Bassini L, Schede HH, Capolupo L, Haj Abdullah Alieh L, Kaysudu I, Venturi F, Hochgerner H, Valente A, … · 2026-09-23
open access unreviewed -
7
Hypertensive stretch regulates endothelial cell inflammation and apoptosis through ceramide metabolism.
Pietromicca-Victor JG, Chitkara S, Muñoz E, Manzar ZA, Bharathi Rajan AP, Bieberich E, Atilla-Gokcumen GE, Al… · 2026-09-02
unreviewed -
8
Intranasal L-DOPA/TPP-engineered extracellular vesicles deliver icariin to ameliorate mitochondrial dysfunction with associated sphingolipid remodeling in Alzheimer's disease models.
Wu B, Wu J, Zhu L, Li A, Fu Y, Lei Z, Wu D, Peng W, Xie L. · 2026-08-19
open access unreviewed -
9
Large-Scale Plasma Proteomics Enhances Prediction of Liver-Related Events Among Individuals With Prediabetes and Type 2 Diabetes: A Prospective Cohort Study in the UK Biobank.
Ye C, Zhang Z, Ding Y, Yu Y, Zhang S, Pan J, Nie S, Li S, Zhang L, Lu L, Wang L, Ji G. · 2026-07-23
cited 1× unreviewed -
10
SMPD1 modulates malignant progress of osteosarcoma through ferroptosis pathway.
Guo C, Liao K, Chen G, Xu K, Yang J, Zhang J, Luo X, Zhang F, Cheng C, Lv XB, Zhang Z. · 2026-05-09
unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.