unreviewed
Acid sphingomyelinase (SMPD1)
1 reactions · 1 pathways
Clinical / pharmacological. Niemann-Pick disease types A and B
What it does, reaction by reaction
1 reactions
Sphingolipid Degradation (Lysosomal) Lipid Metabolism · Lysosome
step 1
Irreversible/directional
Sphingomyelin + H2O -> ceramide + phosphocholine
Converts Sphingomyelin H2O into Ceramide Phosphocholine
› Notes
Deficiency causes Niemann-Pick disease types A/B (cherry-red macula, hepatosplenomegaly, foam cells).
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
0 entries
No regulation recorded for this enzyme in the source documents.
Recent literature
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