Porphobilinogen deaminase (HMBS)
Cofactors used
Clinical / pharmacological. Acute intermittent porphyria: abdominal pain, neuropsychiatric signs, no photosensitivity
What it does, reaction by reaction
Heme Biosynthesis (Porphyrin Pathway) Amino Acid & Nitrogen Metabolism · Mitochondrion + cytosol
4 porphobilinogen → hydroxymethylbilane + 4 NH₃
Converts Porphobilinogen into Hydroxymethylbilane NH3
› Notes
Porphobilinogen deaminase, also called hydroxymethylbilane synthase (HMBS), polymerizes four PBG units using a dipyrromethane cofactor covalently attached to the enzyme. The linear tetrapyrrole product is unstable and is normally consumed immediately.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
Europe PMC · fetched just now · sorted by publication date
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1
HMB supplementation combined with high-intensity functional exercise supports aerobic capacity but not strength in trained and untrained males: a randomized controlled trial.
Durkalec-Michalski K, Murawa M, Steffl M, Podgórski T, Adamczewski J, Marchelek-Myśliwiec M, Jandova T, Vagne… · 2026-07-13
open access unreviewed -
2
Assessing post-mortem interval in cats (Felis catus) through RNA degradation analysis in liver tissue.
Botta L, Divari S, Pregel P, Ricci E, Ressel L, Scaglione FE. · 2026-08-09
unreviewed -
3
Lipid dysregulation in mouse ovarian antral follicles after oral exposure to a human relevant mixture of three phthalates.
Miller KL, Massey T, Metzler V, Adams A, Liu X, Burns K, Porter LR, Snider J, Craig ZR. · 2026-06-06
cited 3× unreviewed -
4
Protein Binding Determination of Cefepime, Flucloxacillin, Meropenem, Piperacillin and Tazobactam by Ultrafiltration in Critically Ill Patients: The Choice of Device Matters.
Gregoire M, Wallis SC, Williams PG, Won H, Hernández-Mitre MP, Abdul-Aziz MH, Roberts JA. · 2026-08-29
open access unreviewed -
5
Early feeding in the hatcher influences physiological indicators of nutritional status and hydration in broiler chicks during the immediate post-hatch period.
Smets R, Eeckhaut V, Blomme F, Van Rysselberghe N, Tuyttens FAM, Duchateau L, Antonissen G. · 2026-07-08
open access unreviewed -
6
Intravenous hemin for prevention of frequent attacks of acute hepatic porphyria - a double-blind placebo controlled pilot study.
Moghe A, Kormos-Hallberg C, Villasante-Tezanos A, Anderson KE. · 2026-09-24
unreviewed -
7
Pharmacological targeting of bunyavirus-induced synaptic impairment prevents neuronal hyperexcitability.
Gorda B, Bouget J, Saini V, Lutz W, Hirschler A, Almeida GM, Brychka D, Bernou C, Partiot E, Delalande F, Sin… · 2026-09-01
open access unreviewed -
8
Validation of Optimal Reference Genes for qRT-PCR in Adipose- and Uterine-Derived Feline Mesenchymal Stem Cells.
Miah R, Lee SY, Song SH, Park DJ, Choe YH, Lee SL, Lee WJ, Jo CH, Bok EY, Lee HJ, Jin YX, Jeong YW, Son YB. · 2026-09-02
open access unreviewed -
9
Small Activating RNAs: A Curated Database and an Overview of Rational Design Principles.
Sušjan-Leite P, Pečan P, Godeša A, Caldana FR, Jerala R. · 2026-09-14
open access unreviewed -
10
Residues Ser83, Arg85, Tyr88, Asn124, and Lys192 of C-Terminal Lipid-Associated Membrane Hemagglutinin Affect <i>Mycoplasma synoviae</i> Agglutination of Erythrocytes.
Si D, Bao S, Guo L, Chen X, Wen F, He X, Wang Q, Shi Y, He S, Li J. · 2026-09-12
open access unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.