Phospholipase A2
Cofactors used
Clinical / pharmacological. Suppressed indirectly by corticosteroids (annexin/lipocortin)
What it does, reaction by reaction
Eicosanoid Synthesis Lipid Metabolism · Cytosol / ER / nuclear membrane
Membrane phospholipid -> arachidonic acid + lysophospholipid
Converts Phospholipid into Arachidonic acid Lysophospholipid
› Notes
Rate-limiting release of the 20:4 omega-6 precursor. Corticosteroids suppress this step.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
Europe PMC · fetched just now · sorted by publication date
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1
Maternal high-fat diet intake ameliorates the progression of nephritis in male lupus-prone offspring via mTOR/NFκB/arachidonic acid signaling cascade.
Liu S, Imai M, Suzuki Y, Sugiyama T, Mogi M. · 2026-04-25
open access unreviewed -
2
Identification of Domain Formation During sPLA2 Activity by Biophotonics.
Pacheco MSF, Vallejo-Cardona AA, Rios-Ibarra CP. · 2027-01-01
unreviewed -
3
Phospholipases: Where Do We Stand?
Malcles L, Wu Z, Snini S, Aloulou A, Noiriel A, Abousalham A. · 2027-01-01
unreviewed -
4
Supramolecular engineering of fibrinogen into a fibrin matrix with enhanced bioactive properties.
Laurenza D, Macrae FL, Sapjanskaite I, Hartley A, Pramanik B, Padilla-Lopategui S, Rose FRAJ, Ariëns RAS, Mat… · 2026-08-20
open access unreviewed -
5
Integrated multi-omics analysis identifies PPAR signaling network associations with metabolic-immune dysregulation and intestinal injury in PDCoV-infected piglets.
Guo X, A C, Ding Y, Zhang Y, Zhang H, Wang J, Zhang Y, Wang T. · 2026-09-27
open access unreviewed -
6
Lower lipoprotein(a) levels in patients with acute lacunar infarction.
Chen X, Chen N, Zhu L, Huang Q, Jiang F. · 2026-09-08
open access unreviewed -
7
Metabolic regulation of oocyte maturation and early embryo development in mammals.
Rong S, Fu Y, Li Y, Jiang YC, Chen L, Zhao Y, Zhu W, Mu L. · 2026-08-06
open access unreviewed -
8
Multi-omics reveals that dietary arachidonic acid reshapes hepatopancreatic lipid remodeling and modulates steroidogenesis-related pathways in mud crab.
Fang F, Yuan Y, Jin M, Wang X, Zhu T, Zhou Q. · 2026-09-02
open access unreviewed -
9
Integrated metagenomic and metabolomic analysis identifies severity-specific inflammatory and metabolic signatures in post-stroke depression.
Chen W, Pan Y, Chen M, Zhou S, Liu X, Sun M, Yang Z, Zhi Y. · 2026-09-14
open access unreviewed -
10
Advances in mosquito gut microbiota: Mechanisms of regulating pathogen transmission and applications in vector control.
Zhao B, Yu L, Wang J, Xia X. · 2026-09-09
open access unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.