Phospholipase A2
Cofactors used
Clinical / pharmacological. Suppressed indirectly by corticosteroids (annexin/lipocortin)
What it does, reaction by reaction
Eicosanoid Synthesis Lipid Metabolism · Cytosol / ER / nuclear membrane
Membrane phospholipid -> arachidonic acid + lysophospholipid
Converts Phospholipid into Arachidonic acid Lysophospholipid
› Notes
Rate-limiting release of the 20:4 omega-6 precursor. Corticosteroids suppress this step.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
Europe PMC · from cache · sorted by publication date
-
1
Bacterial microbiome and flavor metabolome shifts in traditional Hinggan league sauerkraut fermentation.
Yang Y, Zhang H, Shuang Q, Xia YN. · 2026-06-02
open access unreviewed -
2
The value of proteinuria for the administration of rituximab in patients with PLA2R-associated membranous nephropathy: a single-centre retrospective analysis.
Li X, Zhang Y, Xu C, Ke B. · 2026-06-05
open access unreviewed -
3
Multi-omics integration reveals convergent extracellular matrix remodelling and lipid metabolic reprogramming as central axes of adipocyte differentiation from mouse embryonic stem cells.
Al-Sayegh M, Khalili M, Alzaabi M, Sultana M, Ali L, Ali M, El-Hadidi M. · 2026-06-02
open access unreviewed -
4
Antenatal depressive symptoms impair offspring neurodevelopment by inducing maternal gut microbiota dysbiosis during pregnancy.
Zhou F, Wang L, Zhao Y, Hu C, Meng Y, Fan J, Fraser WD, Baillargeon JP, Ouyang F, Lye SJ, Dennis CL, Shen J, … · 2026-05-15
cited 1× open access unreviewed -
5
Gut microbiota in chronic inflammation: the interplay with lipid mediators.
Bao S, Yao C. · 2026-05-06
open access unreviewed -
6
Serum metabolic profiling analysis of Gitelman syndrome using untargeted metabolomics.
Han J, Ma L, Luo H. · 2026-04-29
open access unreviewed -
7
Baicalin ameliorates podocyte injury and renal function impairment in idiopathic membranous nephropathy by inhibiting the AGE/RAGE signaling.
Lou C, Zhou Y, Feng B, Fan X, Xu X, Hu P, Wang X. · 2026-04-20
open access unreviewed -
8
Sirtuin 5-mediated desuccinylation of PRDX6 inhibits ferroptosis and alleviates sepsis-associated acute kidney injury.
Lin W, Dong C, Jiang Q, Lou Y, Wang L, He Z. · 2026-04-10
cited 1× open access unreviewed -
9
Lactate induces renal lipid accumulation and aggravates renal fibrosis by inhibiting the PPARα signaling pathway and fatty acid oxidation.
Wang W, Gao Y, Chen Y, Cheng M, Wei L, Sang Y, Zhang L, Dai R, Wang Y. · 2026-03-10
open access unreviewed -
10
The responsive nucleus: morphological signatures of cellular state.
Pérez-Venteo A, Bosch-Calvet M, Garcia-Cajide M, Mauvezin C. · 2026-02-19
cited 3× open access unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.