Phosphoglycerate mutase
What it does, reaction by reaction
Gluconeogenesis Carbohydrate Metabolism · Cytosol + mitochondrion + ER
2-Phosphoglycerate ↔ 3-phosphoglycerate
Converts 2-Phosphoglycerate into 3-Phosphoglycerate
› Notes
Phosphoglycerate mutase reversibly transfers the phosphate from carbon 2 to carbon 3; the catalytic 2,3-bisphosphoglycerate-dependent mechanism is used by the corresponding isoenzyme.
Glycolysis Carbohydrate Metabolism · Cytosol
3-Phosphoglycerate → 2-phosphoglycerate
Converts 3-Phosphoglycerate into 2-Phosphoglycerate
› Notes
Phosphoglycerate mutase reversibly shifts the phosphate from carbon 3 to carbon 2; the 2,3-bisphosphoglycerate-dependent isoenzyme requires a catalytic phosphohistidine and 2,3-bisphosphoglycerate for priming. No ATP is consumed.
Anaerobic Glycolysis / Lactic Acid Fermentation Energy Metabolism & Cellular Respiration · Cytosol
3-Phosphoglycerate ⇌ 2-phosphoglycerate
Converts 3-Phosphoglycerate into 2-Phosphoglycerate
› Notes
Required cofactor: 2,3-bisphosphoglycerate as a catalytic priming cofactor in the major human enzyme. The reaction is reversible.
Showing all 3 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
Europe PMC · from cache · sorted by publication date
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1
Necroptosis and the RIPK1-RIPK3-MLKL pathway in chronic kidney disease: mechanisms, crosstalk, and therapeutic opportunities.
Lu J, Wang Y, Cheng Y, Zhou S, Liao Y, Zeng J, Zhang S, Tang Y. · 2026-04-27
open access unreviewed -
2
Proteomic analysis may explain differences in <i>Citrus</i> × <i>limon</i> and <i>Citrus</i> × <i>sinensis</i> susceptibility to <i>Trioza erytreae</i>.
Magalhães T, Anjos L, Dandlen SA, Power DM, Pereira JA, Duarte A, Marques N. · 2026-02-18
open access unreviewed -
3
Bacterial cell envelope components of gut commensals: effects in host-microbe interaction.
Vilela Rodrigues T, Lima de Jesus L, Langella P, de Castro Soares S, Jan G, Ariston de Carvalho Azevedo V, Ch… · 2026-01-30
cited 1× open access unreviewed -
4
Imbalance of mitochondria and abnormalities in lipid metabolism in Diabetic Tubulopathy.
Sun C, Li Y, Tao Y, Wu Q, Liu B, Zhou Y. · 2026-01-18
open access unreviewed -
5
Matrine targets Enolase 1 and regulates the glycolysis-lactylation axis to enhance cisplatin sensitivity in triple-negative breast cancer.
Lin L, Xia M, Liang R, Zhu M, Chen X, Zhang J, Cao X. · 2026-06-29
unreviewed -
6
Mitochondrial dynamics and T cells immunity in cancer.
Li X, Zhang M, Wang Y, Li M, Wang T, Liu X. · 2026-06-06
open access unreviewed -
7
Mitochondrial homeostasis imbalance-triggered PANoptosis in traumatic brain and spinal cord injury: from mechanism to therapeutic strategies.
Ye Y, Feng Z, Huang P, Su X, Lu C, Yu Y, Li L, Wang J, Li X. · 2026-06-10
open access unreviewed -
8
Mitophagy-mediated immune evasion: Shared strategies of pathogens.
Li J, Li W, Wang D, Liu Y. · 2026-06-05
open access unreviewed -
9
Tumor cell-derived HSP47 promotes pancreatic Cancer metastasis via Homotrimeric collagen-mediated M2 macrophage polarization.
Ling X, Zhang Y, Zhu L, Xu Z, Bao Y, Lin H, Wu J, Shi J, Liu L, Dong Q. · 2026-05-12
unreviewed -
10
Time-resolved transcriptomics reveals mechanisms of acute and sustained low-pH adaptation in <i>Corynebacterium glutamicum</i>.
Hao Y, Xu J, Sun B, Zhang H, Gu H, Wang Y, Zheng P, Jia K, Zhu Y, Sun J. · 2026-03-23
open access unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.