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unreviewed

Phosphoglycerate mutase

3 reactions · 3 pathways

What it does, reaction by reaction

3 reactions

Gluconeogenesis Carbohydrate Metabolism · Cytosol + mitochondrion + ER

step 6 Reversible

2-Phosphoglycerate ↔ 3-phosphoglycerate

Converts 2-Phosphoglycerate into 3-Phosphoglycerate

› Notes

Phosphoglycerate mutase reversibly transfers the phosphate from carbon 2 to carbon 3; the catalytic 2,3-bisphosphoglycerate-dependent mechanism is used by the corresponding isoenzyme.

Glycolysis Carbohydrate Metabolism · Cytosol

step 8 Reversible

3-Phosphoglycerate → 2-phosphoglycerate

Converts 3-Phosphoglycerate into 2-Phosphoglycerate

› Notes

Phosphoglycerate mutase reversibly shifts the phosphate from carbon 3 to carbon 2; the 2,3-bisphosphoglycerate-dependent isoenzyme requires a catalytic phosphohistidine and 2,3-bisphosphoglycerate for priming. No ATP is consumed.

Anaerobic Glycolysis / Lactic Acid Fermentation Energy Metabolism & Cellular Respiration · Cytosol

step 8 Reversible

3-Phosphoglycerate ⇌ 2-phosphoglycerate

Converts 3-Phosphoglycerate into 2-Phosphoglycerate

› Notes

Required cofactor: 2,3-bisphosphoglycerate as a catalytic priming cofactor in the major human enzyme. The reaction is reversible.

Showing all 3 reactions.

What accelerates and inhibits it

Regulation is pathway-specific, so each context is listed separately

0 entries

No regulation recorded for this enzyme in the source documents.

Recent literature

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Europe PMC · fetched just now · sorted by publication date

  1. 1
    ZO-2 blocks the localization of PGAM5 protein to the mitochondrial membrane and suppresses pancreatic cancer malignancy through metabolic reprogramming.

    Yu S, Ke M, Ma M, Jiang T, Li X, Xie K. · 2026-06-24

    open access unreviewed
  2. 2
    Multi-omics profiling of oxeiptosis-associated biomarkers in cancer.

    Khan A, Alruwaili MM, Alhuthali HM, Alzahrani S, Alrehaili AA, Alshammari A, Siddique MI, Imran M. · 2026-06-20

    unreviewed
  3. 3
    Phosphoglycerate mutase 5 regulates lipid metabolism and mitochondrial homeostasis in hepatocellular cancer cells.

    Guttula PK, Muthusamy G, Liu CC, Devora P, Sasaki E, Butsch T, Gandhi H, Moran J, Gartia MR, Johnston AN. · 2026-08-22

    unreviewed
  4. 4
    Qdr3 Coordinates cellular homeostasis, mitochondrial remodeling, and virulence in <i>Candidozyma auris</i> (<i>Candida auris</i>).

    Munhoz da Rocha IF, Ennis CL, Romagnoli BA, Schemiko K, Rossi SA, da Costa AT, de Oliveira HC, Nobile CJ, Alv… · 2026-07-15

    open access unreviewed
  5. 5
    Advances in SEC61G research: from ER translocon subunit to emerging pan-cancer oncogenic roles.

    Man YN, He ML. · 2026-06-25

    open access unreviewed
  6. 6
    Necroptosis and the RIPK1-RIPK3-MLKL pathway in chronic kidney disease: mechanisms, crosstalk, and therapeutic opportunities.

    Lu J, Wang Y, Cheng Y, Zhou S, Liao Y, Zeng J, Zhang S, Tang Y. · 2026-04-27

    open access unreviewed
  7. 7
    Proteomic analysis may explain differences in <i>Citrus</i> × <i>limon</i> and <i>Citrus</i> × <i>sinensis</i> susceptibility to <i>Trioza erytreae</i>.

    Magalhães T, Anjos L, Dandlen SA, Power DM, Pereira JA, Duarte A, Marques N. · 2026-02-18

    open access unreviewed
  8. 8
    Bacterial cell envelope components of gut commensals: effects in host-microbe interaction.

    Vilela Rodrigues T, Lima de Jesus L, Langella P, de Castro Soares S, Jan G, Ariston de Carvalho Azevedo V, Ch… · 2026-01-30

    cited 4× open access unreviewed
  9. 9
    Reactive oxygen species and cognitive decline: an in-depth analysis.

    García Menéndez S, García Menéndez S, Manucha W. · 2026-01-26

    open access unreviewed
  10. 10
    Imbalance of mitochondria and abnormalities in lipid metabolism in Diabetic Tubulopathy.

    Sun C, Li Y, Tao Y, Wu Q, Liu B, Zhou Y. · 2026-01-18

    cited 3× open access unreviewed

External claims. These come from an index outside this database and are not checked against it. Treat them as leads.