Phosphoglycerate mutase
What it does, reaction by reaction
Gluconeogenesis Carbohydrate Metabolism · Cytosol + mitochondrion + ER
2-Phosphoglycerate ↔ 3-phosphoglycerate
Converts 2-Phosphoglycerate into 3-Phosphoglycerate
› Notes
Phosphoglycerate mutase reversibly transfers the phosphate from carbon 2 to carbon 3; the catalytic 2,3-bisphosphoglycerate-dependent mechanism is used by the corresponding isoenzyme.
Glycolysis Carbohydrate Metabolism · Cytosol
3-Phosphoglycerate → 2-phosphoglycerate
Converts 3-Phosphoglycerate into 2-Phosphoglycerate
› Notes
Phosphoglycerate mutase reversibly shifts the phosphate from carbon 3 to carbon 2; the 2,3-bisphosphoglycerate-dependent isoenzyme requires a catalytic phosphohistidine and 2,3-bisphosphoglycerate for priming. No ATP is consumed.
Anaerobic Glycolysis / Lactic Acid Fermentation Energy Metabolism & Cellular Respiration · Cytosol
3-Phosphoglycerate ⇌ 2-phosphoglycerate
Converts 3-Phosphoglycerate into 2-Phosphoglycerate
› Notes
Required cofactor: 2,3-bisphosphoglycerate as a catalytic priming cofactor in the major human enzyme. The reaction is reversible.
Showing all 3 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
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