Phosphoglucose isomerase
What it does, reaction by reaction
Gluconeogenesis Carbohydrate Metabolism · Cytosol + mitochondrion + ER
Fructose-6-phosphate ↔ glucose-6-phosphate
Converts Fructose-6-phosphate into Glucose-6-phosphate
› Notes
Phosphoglucose isomerase reversibly forms the aldose phosphate. No nucleotide cofactor is required.
Glycolysis Carbohydrate Metabolism · Cytosol
Glucose-6-phosphate → fructose-6-phosphate
Converts Glucose-6-phosphate into Fructose-6-phosphate
› Notes
Phosphoglucose isomerase catalyzes reversible aldose–ketose isomerization through an enediol intermediate; no nucleotide cofactor is consumed. This reversible reaction prepares the molecule for symmetrical cleavage after a second phosphorylation.
Anaerobic Glycolysis / Lactic Acid Fermentation Energy Metabolism & Cellular Respiration · Cytosol
Glucose-6-phosphate ⇌ fructose-6-phosphate
Converts Glucose-6-phosphate into Fructose-6-phosphate
› Notes
Required cofactor: none. The reaction is reversible and prepares the substrate for phosphorylation and symmetric cleavage.
Showing all 3 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
Europe PMC · fetched just now · sorted by publication date
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1
Strategies and applications for alleviating carbon catabolite repression.
Lu M, Ding H, Zhang H, Xu J, Meng R, Li Y, Zhang Z, Zheng P, Zhu Y, Sun J. · 2026-08-20
open access unreviewed -
2
VCP at the crossroads of UPS and autophagy in cancer.
Hitchman CJ, Phillips JI, Park HW, Lu H. · 2026-05-28
open access unreviewed -
3
Trojan horse-inspired vaccine-like nanoparticle with enhanced lubrication and active-passive synergistic anti-inflammation for post-traumatic osteoarthritis treatment.
Yang Y, Ren J, Sun G, Huang K, Zhao X, Poliakov A, Wang Y, Zhang H. · 2026-08-12
open access unreviewed -
4
Combining gene amplification with SEAP-reporter to achieve high expression of recombinant omicron XBB.1.5 spike protein.
Zou Z, Sun PD. · 2026-07-27
unreviewed -
5
Circulating omentin-1 and HMGB1 levels in patients with Hashimoto thyroiditis.
Genc S, Mercantepe F, Aksu O, Can U, Kizilarslanoglu MC, Klisic A. · 2026-06-20
unreviewed -
6
Biodegradable molybdenum intramedullary nails facilitate fracture repair through neutrophil-mediated immune response.
Zhu C, He Y, Zhao Y, Huang Y, Zhang C, Zhou J, Liang H, Qin H, Fang Z, Liu D, Dai J, Li P, Qian J. · 2026-09-01
open access unreviewed -
7
Efficacy of plasma exchange and exchange transfusion in the clinical management of severe hypertriglyceridemia in emergency.
Stefanutti C, Zeppa G, Perrone G, Labbadia G, Galoppi P, Demarco V, Fornari E, Bordugo A, Santelia C, Manciop… · 2026-09-12
open access unreviewed -
8
Rethinking the immune recognition of cell walls in human fungal pathogens: Mechanisms, controversies and translational significance.
Wang R, Peng X, Liu W, Song Z, Yu H. · 2026-09-14
open access unreviewed -
9
Proteomic profiling of cephalic vein reveals potential biomarkers for arteriovenous fistula neointimal hyperplasia in ESRD patients.
Liang L, Gu L, Shi L, Luo Q, Kong X, Wang F. · 2026-09-06
open access unreviewed -
10
The enzyme inhibitory activity of helminth-derived serine protease inhibitor rapidly establishes immune tolerance to ameliorate allergic diseases.
Shi W, Xu N, Liu Y, Bai X, Liu X, Xu N, Liu Y. · 2026-09-06
cited 1× open access unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.