Phosphoglucose isomerase
What it does, reaction by reaction
Gluconeogenesis Carbohydrate Metabolism · Cytosol + mitochondrion + ER
Fructose-6-phosphate ↔ glucose-6-phosphate
Converts Fructose-6-phosphate into Glucose-6-phosphate
› Notes
Phosphoglucose isomerase reversibly forms the aldose phosphate. No nucleotide cofactor is required.
Glycolysis Carbohydrate Metabolism · Cytosol
Glucose-6-phosphate → fructose-6-phosphate
Converts Glucose-6-phosphate into Fructose-6-phosphate
› Notes
Phosphoglucose isomerase catalyzes reversible aldose–ketose isomerization through an enediol intermediate; no nucleotide cofactor is consumed. This reversible reaction prepares the molecule for symmetrical cleavage after a second phosphorylation.
Anaerobic Glycolysis / Lactic Acid Fermentation Energy Metabolism & Cellular Respiration · Cytosol
Glucose-6-phosphate ⇌ fructose-6-phosphate
Converts Glucose-6-phosphate into Fructose-6-phosphate
› Notes
Required cofactor: none. The reaction is reversible and prepares the substrate for phosphorylation and symmetric cleavage.
Showing all 3 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
Europe PMC · from cache · sorted by publication date
-
1
Cancer associated fibroblast-T cell crosstalk promotes purinergic synthesis in non-small cell lung cancer (NSCLC).
Koppensteiner L, Lochenie C, O'Connor RA, Mathieson L, Neilson L, Akram AR. · 2026-07-30
unreviewed -
2
Cellular thermal shift assay of subcellular isolates to evaluate drug-membrane target interactions.
Dogra SK, Kattunga V, Mookerjee SA, Rane A, Chamoli M, Andersen JK. · 2026-06-27
unreviewed -
3
Effects of dinotefuran and its metabolites on the early life stage development of medaka (<i>Oryzias latipes</i>): <i>In vivo</i> and <i>in silico</i> studies.
Hirano M, Inoue D, Uchida M, Takahashi K, Kato K, Okobira T, Ishibashi H, Arizono K, Tominaga N. · 2026-06-12
open access unreviewed -
4
Purinergic activity of circulating extracellular vesicles associates with disease progression in melanoma.
Najjar YG, Hong CS, Menshikova EV, Kirkwood JM, Diergaarde B, Jackson EK, Whiteside TL. · 2026-06-21
open access unreviewed -
5
Engineering of fructose-6-phosphate aldolase for one-carbon conversion to mannitol in a designed biotransformation system.
Wang D, Dong Q, Chen P, Zeng Y, Liu Y, Sun Y, Tan J, Yang J. · 2026-06-05
open access unreviewed -
6
Folate receptor-targeted PEGylated PLGA nanoparticles for the site-specific delivery of hesperidin in epithelial ovarian cancer.
Kharwade R, Mahajan NM, Telange DR, Yadav PN, More SR. · 2026-06-08
unreviewed -
7
Biological-chemical method for synthesizing <i>p</i>-menthane-3,8-diol.
Zuo X, Zhang H, Zhang Z, Ma Y, Zhang C, Lu W. · 2026-05-12
open access unreviewed -
8
Identification of proteins interacting with the N-terminal half of endoribonuclease RNase E in <i>Escherichia coli</i>.
Göpel Y, Durica-Mitic S, Boyko S, Dudys P, Amman F, Schnetz K, Görke B. · 2026-06-02
open access unreviewed -
9
A CRISPR activation screen identifies CH25H as a restriction factor against influenza viruses by targeting accessible cholesterol.
Huang J, Ma K, Ding S, Wang Y, Xiong J, Yi J, Zhang J, He Z, Huang L, Ren X, Zhou J, Chen X, Liu L, Qi W, Wan… · 2026-05-26
open access unreviewed -
10
Dynamic modulation of intercellular adhesion mediated by matriptase-EPCAM/Trop-2 axes is critical for cell extrusion, division, and collective migration.
Kao YA, Wang Q, Lu DD, Umemura S, Lee V, Tsai YH, Barndt RB, Wang JK, Johnson MD, Lin CY. · 2026-05-05
open access unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.