Phosphoglucose isomerase
What it does, reaction by reaction
Gluconeogenesis Carbohydrate Metabolism · Cytosol + mitochondrion + ER
Fructose-6-phosphate ↔ glucose-6-phosphate
Converts Fructose-6-phosphate into Glucose-6-phosphate
› Notes
Phosphoglucose isomerase reversibly forms the aldose phosphate. No nucleotide cofactor is required.
Glycolysis Carbohydrate Metabolism · Cytosol
Glucose-6-phosphate → fructose-6-phosphate
Converts Glucose-6-phosphate into Fructose-6-phosphate
› Notes
Phosphoglucose isomerase catalyzes reversible aldose–ketose isomerization through an enediol intermediate; no nucleotide cofactor is consumed. This reversible reaction prepares the molecule for symmetrical cleavage after a second phosphorylation.
Anaerobic Glycolysis / Lactic Acid Fermentation Energy Metabolism & Cellular Respiration · Cytosol
Glucose-6-phosphate ⇌ fructose-6-phosphate
Converts Glucose-6-phosphate into Fructose-6-phosphate
› Notes
Required cofactor: none. The reaction is reversible and prepares the substrate for phosphorylation and symmetric cleavage.
Showing all 3 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
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