Phosphoglucomutase
What it does, reaction by reaction
Galactose Metabolism Carbohydrate Metabolism · Cytosol
Glucose-1-phosphate ↔ glucose-6-phosphate
Converts Glucose-1-phosphate into Glucose-6-phosphate
› Notes
Phosphoglucomutase reversibly forms glucose-6-phosphate through a glucose-1,6-bisphosphate intermediate. The product can enter glycolysis, glycogenesis, or, in liver, be converted to free glucose by glucose-6-phosphatase.
Glycogenesis (Glycogen Synthesis) Carbohydrate Metabolism · Cytosol (glycogen particle)
Glucose-6-phosphate ↔ glucose-1-phosphate
Converts Glucose-6-phosphate into Glucose-1-phosphate
› Notes
Phosphoglucomutase reversibly transfers the phosphate through a glucose-1,6-bisphosphate intermediate; a catalytic phosphoserine is primed by glucose-1,6-bisphosphate. This reaction directs glucose carbon toward activated-sugar formation.
Glycogenolysis (Glycogen Breakdown) Carbohydrate Metabolism · Cytosol + ER (liver)
Glucose-1-phosphate ↔ glucose-6-phosphate
Converts Glucose-1-phosphate into Glucose-6-phosphate
› Notes
Cytosolic phosphoglucomutase reversibly transfers the phosphate via glucose-1,6-bisphosphate. In muscle, glucose-6-phosphate enters glycolysis; in liver it is prepared for export.
Showing all 3 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
Europe PMC · fetched just now · sorted by publication date
-
1
Autosomal dominant gain-of-function mutations in LCP1 cause a syndromic neutropenia and immunodeficiency.
Yu L, Zhou B, Liu W, Li W, Wei Q, Zhang Y, Li C, Li W, Li Y, Li G, Sun G, Gan R, Chen R, Zhang W, Zeng A, Zha… · 2026-05-12
open access unreviewed -
2
Impact of leucine-rich diet on placenta's proteomic and metabolomic profiles of pregnant tumor-bearing rats.
Dos Santos IF, Salgado CM, Carregari VC, Dos Santos RW, de Souza DM, Viana LR, Gomes-Marcondes MCC. · 2026-05-14
open access unreviewed -
3
Efficient whole-cell biotransformation for gastrodin production via glycosyltransferase engineering and process optimization.
Wang X, Zhang J, Li T, Wang F, Wang Z, Li X. · 2026-04-06
open access unreviewed -
4
Stepwise phage resistance and collateral phage susceptibility in <i>Klebsiella pneumoniae</i>.
Yin X, Feng Y, Luo H, Fang Q, Yu J, McNally A, Zong Z. · 2026-05-29
cited 1× open access unreviewed -
5
An update on regulation of the polymodal TRPV4 channel by protein phosphorylation.
Parthasarathy A, Zhang DX. · 2026-01-19
open access unreviewed -
6
Small regulatory RNAs mediated regulation of virulence and host-pathogen interaction in the Gram-negative ESKAPE pathogens.
Li L, Zhang Z, Zhu H, Cui K, Song X, Wang Z, Chen L, Yu Z, Zhang W, Sun H, Yu Z, Duan Y, Li M. · 2025-12-18
cited 4× open access unreviewed -
7
Essential Oral Single Nutritional Therapy Products for Inherited Metabolic Diseases: Evidence and Consensus Assessment Using a Modified Delphi Method.
Stolwijk NN, Penninx BMF, Bosch AM, Langeveld M, Salomons GS, Hollak CEM, Essential Nutritional Therapy Produ… · 2026-11-01
open access unreviewed -
8
Extreme Hydrolyzable Tannin Accumulation in Aphid-Induced Galls and Laccase-Mediated Tolerance in Schlechtendalia chinensis.
Lu Q, Liu J, Wang W, Zhang X, He R, Cao G, King-Jones K, Chen H. · 2026-10-04
unreviewed -
9
Integrating genome-wide association study and transcriptomic profiling identifies candidate genes underlying soluble solids content in melon (<i>Cucumis melo</i> L.).
Niu X, Li Q, Cao L, Liu Y, Qiang J, Lian Z, Xie Y, Meng Q, Yan W, Wang P, Li X, Mao W, Hou J, Li L, Yang L, F… · 2026-05-13
open access unreviewed -
10
Design rules for bioorthogonal glycan-based tools.
Hoddle F, Schmidt SD, Sridhar S, Schumann B. · 2026-10-01
open access unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.