Phosphoglucomutase
What it does, reaction by reaction
Galactose Metabolism Carbohydrate Metabolism · Cytosol
Glucose-1-phosphate ↔ glucose-6-phosphate
Converts Glucose-1-phosphate into Glucose-6-phosphate
› Notes
Phosphoglucomutase reversibly forms glucose-6-phosphate through a glucose-1,6-bisphosphate intermediate. The product can enter glycolysis, glycogenesis, or, in liver, be converted to free glucose by glucose-6-phosphatase.
Glycogenesis (Glycogen Synthesis) Carbohydrate Metabolism · Cytosol (glycogen particle)
Glucose-6-phosphate ↔ glucose-1-phosphate
Converts Glucose-6-phosphate into Glucose-1-phosphate
› Notes
Phosphoglucomutase reversibly transfers the phosphate through a glucose-1,6-bisphosphate intermediate; a catalytic phosphoserine is primed by glucose-1,6-bisphosphate. This reaction directs glucose carbon toward activated-sugar formation.
Glycogenolysis (Glycogen Breakdown) Carbohydrate Metabolism · Cytosol + ER (liver)
Glucose-1-phosphate ↔ glucose-6-phosphate
Converts Glucose-1-phosphate into Glucose-6-phosphate
› Notes
Cytosolic phosphoglucomutase reversibly transfers the phosphate via glucose-1,6-bisphosphate. In muscle, glucose-6-phosphate enters glycolysis; in liver it is prepared for export.
Showing all 3 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
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