P-glycoprotein (MDR1/ABCB1); MRP (ABCC) transporters
Cofactors used
What it does, reaction by reaction
Phase III - Efflux & Excretion Xenobiotic & Drug Metabolism · Plasma membrane (ABC transporters)
Conjugated metabolite (intracellular) + ATP -> extracellular metabolite + ADP + Pi
Converts Conjugated metabolite (intracellular) ATP into Extracellular metabolite ADP Pi
› Notes
ATP-binding-cassette efflux at the canalicular, intestinal and blood-brain barrier membranes; a major source of drug interactions and of tumour multidrug resistance.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
Europe PMC · fetched just now · sorted by publication date
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1
Expression of ABCB1, ABCC1 and 3 and ABCG2 in glioblastoma and their relevance in relation to clinical survival surrogates.
Roy LO, Lemelin M, Blanchette M, Poirier MB, Aldakhil S, Fortin D. · 2022-11-07
cited 7× unreviewed -
2
Comparative Toxicological Evaluation of Tattoo Inks on Two Model Organisms.
Carotenuto R, Fogliano C, Rienzi M, Siciliano A, Salvatore MM, De Tommaso G, Benvenuto G, Galdiero E, Guida M. · 2021-12-09
cited 7× open access unreviewed -
3
Pharmacogenomics of COVID-19 therapies.
Takahashi T, Luzum JA, Nicol MR, Jacobson PA. · 2020-08-18
cited 52× open access unreviewed -
4
Cell Migration Related to MDR-Another Impediment to Effective Chemotherapy?
Kryczka J, Boncela J. · 2018-02-05
cited 18× open access unreviewed -
5
First evidence for toxic defense based on the multixenobiotic resistance (MXR) mechanism in Daphnia magna.
Campos B, Altenburger R, Gómez C, Lacorte S, Piña B, Barata C, Luckenbach T. · 2014-01-11
cited 44× unreviewed -
6
Are circulating autoantibodies to ABCC3 transporter a potential biomarker for lung cancer?
Liu L, Liu N, Liu B, Yang Y, Zhang Q, Zhang W, Yu P, Jin Y, Guo J, Guan S, Sun S, Miao L, Wei J. · 2012-06-15
cited 14× unreviewed -
7
Vincristine transcriptional regulation of efflux drug transporters in carcinoma cell lines.
Huang R, Murry DJ, Kolwankar D, Hall SD, Foster DR. · 2006-04-18
cited 53× unreviewed -
8
Expression of ABCB1, ABCC1 and 3 and ABCG2 in glioblastoma and their relevance in relation to clinical survival surrogates.
Roy L, Lemelin M, Blanchette M, Poirier M, Aldkihl S, Fortin D. · Research Square · 2022-09-16
unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.