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unreviewed

OMP decarboxylase (UMP synthase domain 2)

1 reactions · 1 pathways

Clinical / pharmacological. Hereditary orotic aciduria (second UMP synthase domain)

What it does, reaction by reaction

1 reactions

Pyrimidine De Novo Synthesis (through to UMP, then CTP/dTMP) Nucleotide Metabolism · Cytosol (one mitochondrial step)

step 6 Irreversible/directional

OMP → UMP

Converts Orotidine 5'-monophosphate (OMP) into UMP

› Notes

OMP decarboxylase, the second UMP synthase activity, catalyzes OMP → UMP + CO2. This is one of the most proficient known enzymatic decarboxylations and commits the incorporated ribose nucleotide to the uracil nucleotide pool.

Showing all 1 reactions.

What accelerates and inhibits it

Regulation is pathway-specific, so each context is listed separately

0 entries

No regulation recorded for this enzyme in the source documents.

Recent literature

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Europe PMC · fetched just now · sorted by publication date

  1. 1
    Enhanced lactose utilization from milk enriched in Uridine-5'-monophosphate drives hepatic energy storage in young mammals.

    Gao LM, Liu L, Yang XD, Long CM, Wu X. · 2026-06-01

    open access unreviewed
  2. 2
    Metabolic regulation of uridine in diabetic kidney disease and its pharmacological modulation by schisandrin B.

    Yuan Y, Yu L, Gu Y, Liu X, Bi C, Li Y, Wang Y, Yang S, Yang L, Ning L, Yang C, Huang W, Wei J, Li Y. · 2026-08-27

    unreviewed
  3. 3
    A comprehensive review on apoptotic miRNAs and antagomiRs in breast cancer: Enhancing radio sensitization.

    Najafi-Amiri M, Pourhabib-Mamaghani M, Aghaee-Bakhtiari SH, Bahreyni-Toossi MT, Azimian H. · 2026-04-22

    open access unreviewed
  4. 4
    Chromatin interaction landscape of epimorphic regeneration in teleost fish

    Jia X, Zhang X, Lin W, Ren T, Liu S, Lou Y, Wang W. · 2026-10-09

    open access unreviewed
  5. 5
    GPX1 drives cuproptosis-ferroptosis resistance in cold tumors.

    Yang S, Zhang C, Mei Z, Ye Q, Guo G, Zhu G, Zheng X, Cui Y, Gu W, Zhou Y, Liu G, Wang G, Yang Z. · 2026-07-02

    unreviewed
  6. 6
    Mesenchymal stem cell-derived extracellular vesicle treatment of induced pluripotent stem cell-derived motor neurons with different amyotrophic lateral sclerosis genetic backgrounds.

    Varderidou-Minasian S, Jakobs CE, Pasteuning-Vuhman S, Gal L, Timmers A, Altelaar M, Lorenowicz MJ, Pasterkam… · 2026-02-05

    open access unreviewed
  7. 7
    Gut microbiota-mediated modulation of circadian rhythms: Physiological and molecular impacts of dietary composition and feeding time.

    Koh YC, Chang CC, Pan MH. · 2026-09-01

    open access unreviewed
  8. 8
    Japanese encephalitis virus reprograms host pyrimidine metabolism to facilitate viral replication.

    Gu J, Fan C, Xiang S, Si Y, Zhu B, Cao S, Ye J. · 2026-07-31

    open access unreviewed
  9. 9
    The GPX3-VCAM1 Axis Gates Pro-Fibrotic Tubule Cell Fate in Hyperuricemic Nephropathy.

    Qi Y, Zhao Q, Lve Y, Yuan Y, Zhou T, Yuan Y, Wu D, Tang Y, Liu Y, Li Z, Jiang C, Ding Q. · 2026-09-09

    open access unreviewed
  10. 10
    Evaluation of peak alignment performance of commercial and open-source tools for GC×GC-MS based non-targeted screening.

    Rebryk A, van Herwerden D, Samanipour S, Haglund P. · 2026-09-01

    open access unreviewed

External claims. These come from an index outside this database and are not checked against it. Treat them as leads.