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unreviewed

N-acetyltransferase (NAT1/NAT2)

1 reactions · 1 pathways

Cofactors used

Acetyl-CoA

Clinical / pharmacological. Slow acetylators: isoniazid neuropathy, hydralazine/procainamide lupus

What it does, reaction by reaction

1 reactions

Phase II - Conjugation Xenobiotic & Drug Metabolism · Cytosol + ER

step 4 Irreversible/directional

Substrate + acetyl-CoA -> acetylated metabolite + CoA-SH

Converts Acetyl-CoA into Acetylated metabolite CoA-SH

› Notes

NAT2 slow-acetylator status predisposes to isoniazid neuropathy and hydralazine-induced lupus.

Showing all 1 reactions.

What accelerates and inhibits it

Regulation is pathway-specific, so each context is listed separately

0 entries

No regulation recorded for this enzyme in the source documents.

Recent literature

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Europe PMC · from cache · sorted by publication date

  1. 1
    Gut microbiota and diet in colorectal cancer: Converging determinants of carcinogenesis.

    Thakur BK, Choudhury SR, Turpin W, Martin A. · 2026-05-04

    open access unreviewed
  2. 2
    Diagnosis, evaluation, and management of patients with non-muscle invasive bladder cancer.

    Manivasagam SS, Kassim A, Raman JD. · 2026-02-09

    open access unreviewed
  3. 3
    Cannabidiol lymphatic transport after oral administration assessed using a novel thoracic lymph duct cannulated conscious pig model.

    Rizov V, Lukáč P, Mlček M, Kozlík P, Křížek T, Jelínek P, Šodek P, Sklenárová M, Paulusová V, Symkanych O, St… · 2025-12-29

    open access unreviewed
  4. 4
    Toxicity assessment of three emerging bisphenols (BPA, BPAP and BPC) and their binary mixtures in an advanced in vitro 3D HepG2 cell model.

    Štampar M, Ravnjak T, Štern A, Žegura B. · 2026-07-01

    unreviewed
  5. 5
    Influence of NAT2 genetic variability on glycemic control in type 2 diabetes.

    Al-Azzam N, Al-Reshiq R, Elsalem L, Abu Mousa BM, Mhedat K, Alfreahat Z, Saadeh N. · 2026-06-01

    unreviewed
  6. 6
    Characterization of NAT2 Using Long-Read Sequencing: Allele, Diplotype, and Phenotype Call Accuracy Compared to Other Testing Strategies.

    John S, Boone EC, Yoo B, Ramsey LB, Gaedigk A. · 2026-08-09

    unreviewed
  7. 7
    Genetic Landscape of NAT2 in the Moroccan Population: Implications for Isoniazid Pharmacogenetics in Tuberculosis.

    Benyahya N, El-Hamri MA, Lyahyai J, Ratbi I, Cherkaoui I, Rchiad Z, Sefiani A. · 2026-08-01

    unreviewed
  8. 8
    Acetylation-modified phosphoglycerate dehydrogenase is associated with enhanced serine biosynthesis and one‑carbon metabolism, supporting heat resistance in Pleurotus ostreatus.

    Hu Y, Zheng X, Du R, Liu Q, Chen Z, Chen Y, Qi YC, Wang F, Wen Q, Shen J. · 2026-06-25

    unreviewed
  9. 9
    Integrated mesenchymal and extracellular cues drive bioengineered liver tissue formation and function.

    Ye S, Wang Z, Dirk Delemarre M, Liv N, van den Dikkenberg A, Vermonden T, van der Laan L, Malda J, Spee B, G … · 2026-06-09

    open access unreviewed
  10. 10
    Acetylator status-guided rapid reintroduction of isoniazid in tuberculosis patients with drug-induced hepatotoxicity.

    van Arkel C, Stemkens R, Magis-Escurra C, Hoefsloot W, Carpaij N, van Ingen J, van Crevel R, van Laarhoven A,… · 2026-06-05

    open access unreviewed

External claims. These come from an index outside this database and are not checked against it. Treat them as leads.