Mitochondrial malate dehydrogenase
Cofactors used
What it does, reaction by reaction
Gluconeogenesis Carbohydrate Metabolism · Cytosol + mitochondrion + ER
Oxaloacetate + NADH + H+ ↔ malate + NAD+
Converts Oxaloacetate NADH H+ into Malate NAD+
› Notes
Mitochondrial malate dehydrogenase reduces oxaloacetate to malate using NADH when oxaloacetate must be exported and cytosolic NADH is needed. Oxaloacetate cannot directly cross the inner mitochondrial membrane; malate is transported to the cytosol and reoxidized by cytosolic malate dehydrogenase in the next step. When gluconeogenic carbon enters as lactate, cytosolic lactate dehydrogenase supplies NADH, and mitochondrial PEP formation/export can be used instead.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
Europe PMC · from cache · sorted by publication date
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1
The role of protein palmitoylation in disease pathogenesis and therapeutic innovation.
Lin X, Xing J, Jia K, Liu S, Liu Y, Gu Y, Guo K, Yi J. · 2026-05-29
open access unreviewed -
2
Co-transplantation of pancreatic islets with adipose-derived mesenchymal stem cells in vascularized kidney ECM scaffolds to restore type 1 diabetes mellitus.
Choi M, Shanto PC, Fahad MAA, Bae SH, Lee BT. · 2026-06-04
open access unreviewed -
3
PM<sub>2.5</sub> exposure impairs mitochondrial function and myocardial contractility in cardiac organoids via the Sirt3/Mdh2 pathway.
Tian L, Li J, Lv J, Liu Z, Liang C, Yang S, Sun Z, Duan J. · 2026-06-29
unreviewed -
4
Revealing the transcriptional profile of fish muscle cells in vitro and in vivo: Insights to improve fish muscle culture.
Zanella BTT, Perez ÉS, Dos Santos Barbosa MF, Valente JS, Duran BOS, Dal-Pai-Silva M. · 2026-03-10
unreviewed -
5
Dexmedetomidine Alleviates Cardiomyocyte Senescence Induced by Ischemia-Reperfusion Injury via Inhibiting the MDH2/NF-κB Pathway.
Liu G, Du X. · 2026-08-05
unreviewed -
6
Sterol regulatory element‑binding proteins: Master regulators of lipid metabolic reprogramming in cancer and emerging therapeutic targets (Review).
Liu Q, Wang R, Li Z, Liu Y, Wu L, Zhao Y, Yang J. · 2026-06-05
open access unreviewed -
7
Identifying key pathways and genes in the progression of wooden breast across multiple broiler lines using weighted gene co-expression network analysis.
Yuan H, Xu K, Xu Q, Liu S, Wang S. · 2026-01-07
unreviewed -
8
Nigericin-Triggered Phosphodynamics in Inflammasome Formation and Pyroptosis.
Bhushan V, Bradfield CJ, Saha S, Yoon SH, Fraser IDC, Nita-Lazar A. · 2025-09-02
cited 3× unreviewed -
9
Integrated proteomics and machine learning for identifying candidate serum biomarkers in acute myocardial infarction-complicated cardiogenic shock: a prospective exploratory study.
Wang X, Xiao QF, Huang FY, Wang S, Xu Y, Pu XB, Yang Y, Chen M, Wei X. · 2026-07-20
unreviewed -
10
Spatial transcriptomics reveals the molecular dynamics of follicular development in the yak ovary under high-altitude hypoxia.
Li X, Li Y, Zhang C, Wang Y, Chen Z, Zeng R, Cen Y, Yang L, Yin S, Xiong Y, Xiong X, Li J. · 2026-07-15
unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.