Mitochondrial malate dehydrogenase
Cofactors used
What it does, reaction by reaction
Gluconeogenesis Carbohydrate Metabolism · Cytosol + mitochondrion + ER
Oxaloacetate + NADH + H+ ↔ malate + NAD+
Converts Oxaloacetate NADH H+ into Malate NAD+
› Notes
Mitochondrial malate dehydrogenase reduces oxaloacetate to malate using NADH when oxaloacetate must be exported and cytosolic NADH is needed. Oxaloacetate cannot directly cross the inner mitochondrial membrane; malate is transported to the cytosol and reoxidized by cytosolic malate dehydrogenase in the next step. When gluconeogenic carbon enters as lactate, cytosolic lactate dehydrogenase supplies NADH, and mitochondrial PEP formation/export can be used instead.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
Europe PMC · from cache · sorted by publication date
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1
Natural products targeting hepatitis B virus X protein and HBx-associated pathways in HBV-related hepatocellular carcinoma: mechanisms and therapeutic potential.
Nguyen TNA, Thongsri P, Pewkliang Y, Chomnawang MT, Thirapanmethee K, Sa-Ngiamsuntorn K. · 2026-09-04
open access unreviewed -
2
Bioinspired 0D mitochondrial bioenergetic actuators rewire cartilage progenitor cell metabolism for osteoarthritis remission.
Lin W, Chen Z, Liu W, Wang X, Song W, He A, Mao Y, Guo H, Jiang Z, Zhou C, Yu Y, Liu W. · 2026-07-01
open access unreviewed -
3
The role of protein palmitoylation in disease pathogenesis and therapeutic innovation.
Lin X, Xing J, Jia K, Liu S, Liu Y, Gu Y, Guo K, Yi J. · 2026-05-29
open access unreviewed -
4
The Maintenance of Dysmyelinated Small-Diameter Axons by 14-3-3s in the Central Nervous System.
Yamada N, Saito H, Takahashi R, Fujisato M, Hosoda Y, Sasaki B, Yamada M, Abe S, Hayashi C, Yoshimoto A, Ohka… · 2026-11-01
open access unreviewed -
5
Spatial transcriptomics reveals the molecular dynamics of follicular development in the yak ovary under high-altitude hypoxia.
Li X, Li Y, Zhang C, Wang Y, Chen Z, Zeng R, Cen Y, Yang L, Yin S, Xiong Y, Xiong X, Li J. · 2026-07-15
unreviewed -
6
Co-transplantation of pancreatic islets with adipose-derived mesenchymal stem cells in vascularized kidney ECM scaffolds to restore type 1 diabetes mellitus.
Choi M, Shanto PC, Fahad MAA, Bae SH, Lee BT. · 2026-06-04
open access unreviewed -
7
Lactate Signal: Modulator of Cellular Energy Production and Anabolism
Wang H, Yang S, Xu W. · 2026-10-08
open access unreviewed -
8
Cell death in ischemia-reperfusion injury: beyond a single-cell-death perspective.
Yao C, Wu Q, Wang Z, Wang C, Zhang W, Bo L. · 2026-10-01
open access unreviewed -
9
Comparative Transcriptomic Analysis of In Vitro Matured Oocytes From Cyclic and Prepubertal Gilts Reveals Distinct Molecular Patterns.
Cabrera-Gómez CG, Gascón-Collado D, Blanco-Cueto P, Pequeño B, Rodríguez-Martínez H, Martínez-Serrano CA. · 2026-10-01
open access unreviewed -
10
Remodeling of mitochondrial dynamics by metabolic pathways couples to oncogenic growth in <i>GNAS</i> (Gα<sub>s</sub>) mutant pancreas cancer.
Hagedorn GA, Spieser JC, Hirai N, Sato Y, Valentine J, Jiang H, Wang W, Czyzyk-Krzeska MF, Patra KC. · 2026-09-30
open access unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.