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unreviewed

Mitochondrial aspartate aminotransferase (GOT2)

1 reactions · 1 pathways

Cofactors used

PLP (B6) · B6 (Pyridoxine)

What it does, reaction by reaction

1 reactions

Malate-Aspartate Shuttle Energy Metabolism & Cellular Respiration · Cytosol + inner mitochondrial membrane

step 4 Reversible

Oxaloacetate + glutamate <-> aspartate + alpha-ketoglutarate (matrix)

Converts Oxaloacetate Glutamate < into Aspartate Alpha-ketoglutarate

› Notes

Oxaloacetate cannot cross the membrane, so it leaves as aspartate.

Showing all 1 reactions.

What accelerates and inhibits it

Regulation is pathway-specific, so each context is listed separately

0 entries

No regulation recorded for this enzyme in the source documents.

Recent literature

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Europe PMC · from cache · sorted by publication date

  1. 1
    Aspartate-Glutamate Carrier 1 (&lt;i&gt;SLC25A12&lt;/i&gt;) Deficiency: Malate-Aspartate Shuttle Failure, Neurodevelopmental Epileptic Encephalopathy, and Ketone-Based Metabolic Therapy.

    Murano M, Iaconisi GN, Monné M, Ahmed A, Fiermonte G, Capobianco L, Dolce V. · 2026-05-15

    open access unreviewed
  2. 2
    A shift in the cellular redox state redirects aspartate for export under glucose deprivation.

    Konrad B, Bluemel G, Haitzmann T, Frech T, Vandekeere A, Planque M, Bubalo V, Schindlmaier K, Jäger V, Dengle… · 2026-03-03

    open access unreviewed
  3. 3
    Mitochondrial Ca&lt;sup&gt;2+&lt;/sup&gt; Signaling at the Tripartite Synapse: A Unifying Framework for Glutamate Homeostasis, Metabolic Coupling, and Network Vulnerability.

    Mancuso M, Mezzalira F, Vignoli B, Greotti E. · 2026-01-20

    cited 1× open access unreviewed
  4. 4
    Network pharmacology and molecular docking reveal antiviral mechanisms of silver nanoparticles synthesized by Oscillatoria sp. against HCV pathogenesis.

    Azmy L, Al-Olayan E, Abdelhamid MAA, Ibraheem IBM, Zayed A, Gheda SF, Youssif KA, Abou-Zied HA, Abdelmohsen U… · 2025-12-12

    cited 1× open access unreviewed
  5. 5
    Can the Quality of Semen Affect the Fertilisation Indices of Turkey Eggs?

    Orzołek A, Dziekońska A, Skorynko P, Ner-Kluza J. · 2025-11-13

    open access unreviewed
  6. 6
    An inherited mitochondrial DNA mutation remodels inflammatory cytokine responses in macrophages and in vivo in mice.

    Marques E, Burr SP, Casey AM, Stopforth RJ, Yu CS, Turner K, Wolf DM, Dilucca M, Paupe V, Chowdhury SR, Tyrre… · 2025-11-20

    cited 5× open access unreviewed
  7. 7
    Metal-related cell death and its application in pancreatic cancer.

    Wang C, Ja Y, Liu T, Lin K, Huang L, Ren C, Zhou S, Sun H, Kong H, Chen Z, Dai S. · 2025-10-17

    open access unreviewed
  8. 8
    Unlocking the Role of Metabolic Pathways in Brain Metastatic Disease.

    Pinto M, Violante S, Cascão R, Faria CC. · 2025-05-13

    cited 3× open access unreviewed
  9. 9
    Mitochondrial aspartate aminotransferase (GOT2) protein as a potential cryodamage biomarker in rooster spermatozoa cryopreservation.

    Zong Y, Li Y, Sun Y, Han X, Yuan J, Ma L, Ma H, Chen J. · 2024-12-18

    cited 2× open access unreviewed
  10. 10
    Genetics and biology of pancreatic ductal adenocarcinoma.

    Ying H, Kimmelman AC, Bardeesy N, Kalluri R, Maitra A, DePinho RA. · 2025-01-07

    cited 20× open access unreviewed

External claims. These come from an index outside this database and are not checked against it. Treat them as leads.