Microsomal triglyceride transfer protein (MTP)
What it does, reaction by reaction
Lipoprotein Metabolism (Exogenous and Endogenous Pathways: chylomicrons, VLDL, LDL, HDL) Lipid Metabolism · Intestine, liver, plasma, capillary endothelium
Nascent chylomicron assembly: TAG/cholesteryl ester + apoB-48 → chylomicron
Converts TAG/cholesteryl ester ApoB-48 into Chylomicron
› Notes
Microsomal triglyceride transfer protein (MTP) loads lipids onto newly translated apoB-48 in intestinal ER; further lipidation and Golgi processing create nascent chylomicrons. ApoB-48 is generated by intestinal APOB mRNA editing and is obligatory for particle assembly; MTP-mediated apoB lipidation is the critical assembly step. Chylomicrons enter lymph, then systemic plasma via the thoracic duct.
Hepatic TAG/cholesteryl ester + apoB-100 → nascent VLDL
Converts ApoB-100 into Nascent VLDL
› Notes
Hepatic MTP transfers lipids to full-length apoB-100 in ER; additional TAG lipidation produces VLDL, which is secreted into plasma. Availability of hepatic fatty acids from de novo lipogenesis, adipose NEFA influx, and dietary remnants controls VLDL-TAG output. ApoB-100 is required for VLDL assembly and later serves as the LDLR ligand.
Showing all 2 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
Lipoprotein Metabolism (Exogenous and Endogenous Pathways: chylomicrons, VLDL, LDL, HDL)
ApoB synthesis and luminal lipid availability
MTP inhibitors; severe lipid shortage
Insulin resistance and hepatic fatty-acid influx can increase VLDL production; regulation is largely transcriptional/substrate-driven
Recent literature
Europe PMC · from cache · sorted by publication date
-
1
The Crimean-Congo haemorrhagic fever virus hijacks the liver lipid metabolic pathway for virion production.
Gautam A, Zhong L, Ogire E, Bodoirat S, Riedmiller I, Sander WJ, Boson B, Gandhi A, Burlaud-Gaillard J, Amira… · 2026-03-30
open access unreviewed -
2
HCV-Induced Hepatocarcinogenesis: Molecular Mechanisms, Persistent Cancer Risk, and Future Perspectives
Jovanović-Ćupić S, Krajnović M, Todorović L, Božović A, Galun D. · 2026-06-01
open access unreviewed -
3
Microsomal triglyceride transfer protein restricts steroid production in Leydig cells by regulating SREBP2.
Chattopadhyay A, Tirumalasetty MB, Palaia T, Gangula B, Ruoff R, Miao QR, Hussain MM. · 2026-04-20
cited 1× open access unreviewed -
4
GPR182 is a lipoprotein receptor for dietary fat absorption.
Sun Z, Torphy RJ, Miller EN, Darehshouri A, Vigil I, Terai T, Eck E, Sun Y, Guo Y, Fykstra DP, Yee EJ, Hu J, … · 2026-03-24
open access unreviewed -
5
Lomitapide, a Microsomal Triglyceride Transfer Protein Inhibitor, in Homozygous Familial Hypercholesterolemia: A Systematic Review and Meta-Analysis of Efficacy and Safety.
Nasser M, Mohammed HE, Haseeb ME, Darwish MK, Hanen G, Abdelaziz NA, Heiba AH, Shata A, Abdelkader MS. · 2025-08-26
cited 2× open access unreviewed -
6
New approaches of N-acetylcysteine on fatty acid transport and metabolism in a rat model of MASLD induced by high-fat diet.
Sztolsztener K, Croos B, Chabowski A. · 2026-05-31
open access unreviewed -
7
Hepatitis C Virus and Type 2 Diabetes: Mechanisms, Clinical Impact, and Post-DAA Management.
Chang SS, Liu CH, Chan SY, Lin LT. · 2026-05-01
cited 1× open access unreviewed -
8
Research progress on the molecular mechanisms of tanshinone IIA in the treatment of cardiovascular and cerebrovascular diseases (Review).
Pei W, Lu P, Ding C, Li Y, Li Y. · 2026-03-13
cited 1× open access unreviewed -
9
Severe polyarterial involvement in a 16-year-old with homozygous familial hypercholesterolaemia: a case report.
Benabdellah M, Mesfioui MB, El Ouartassi H, El Boussaadani B, Raissuni Z. · 2026-03-26
open access unreviewed -
10
Lipid homeostasis plays a critical role in inherited and acquired retinal diseases.
Bhattacharyya A, Choudhary V. · 2026-04-16
open access unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.