What it does, reaction by reaction
Purine De Novo Synthesis (IMP synthesis through to AMP/GMP) Nucleotide Metabolism · Cytosol
AIR → carboxyaminoimidazole ribonucleotide (CAIR)
Converts 5-Aminoimidazole ribonucleotide (AIR) into Carboxyaminoimidazole ribonucleotide (CAIR)
› Notes
AIR carboxylase catalyzes AIR + CO2 (derived from bicarbonate) → CAIR. In mammalian cells, the class II AIR carboxylase activity of PAICS performs direct carboxylation and does not require ATP; this differs from the two-enzyme, ATP-dependent bacterial route. The carboxyl carbon becomes C6 of the purine ring.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
Europe PMC · fetched just now · sorted by publication date
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1
Integrating bulk and single-cell transcriptomic data to construct a risk model for histidine metabolism-related epithelial cell features in lung adenocarcinoma, predicting prognosis and immune landscape.
Mao C, Zhou L. · 2026-04-28
open access unreviewed -
2
Guanidinoacetic acid improves flesh quality associated with collagen synthesis and nucleotide metabolism in gibel carp CAS V (<i>Carassius gibelio</i>, CAS V).
Wang Y, Zhang Y, Wu L, Li C, Chen Q, Han D, Liu H, Zhang Z, Xie S, Jin J. · 2026-04-03
open access unreviewed -
3
Compound Heterozygous Variants in the PAICS Gene Integrate the Previously Described Divergent Phenotypes.
Monti L, Isidori F, Capriotti E, Minicucci A, Michelangelo B, Di Mitri M, Scarano E, Lima M, Pippucci T, Seve… · 2026-08-08
unreviewed -
4
N6-methyladenosine-mediated upregulation of PAICS promotes lung-adenocarcinoma metastasis via the integrin-FAK signaling.
Zhang M, Zhu J, Zhang H, Zhang J, Zhao J, Chen Q, Zeng Y, Li J, Huang JA, Liu Z. · 2026-07-23
unreviewed -
5
Alphavirus nsP3 as a multifunctional orchestrator of virus-host interplay.
Pimenta-Pereira AA, Lubinski B, Campos RK. · 2026-06-15
unreviewed -
6
Gene Expression and Structural Differences Underpinning Black and White Colouration in Spiders.
Salgado-Roa FC, Stuart-Fox D, Ospina-Rozo L, Medina I. · 2026-06-01
open access unreviewed -
7
Integrated Single-Cell Virtual Knockout and Machine Learning Analyses Reveal a Protective Role of CKAP2 in Gastric Cancer.
Yang J, Qiu Z, Song W, Liu X, Ouyang T, Shu J, Wang J, Yang Y. · 2026-06-01
open access unreviewed -
8
Host metabolic responses to SARS-CoV-2 and influenza viruses: parallels and contrasts.
Terra C, Terrier O, Le Gouellec A. · 2026-06-02
open access unreviewed -
9
A small molecule inhibitor of RNA-binding protein IGF2BP3 shows anti-leukemic activity.
Jaiswal AK, Scherer GM, Thaxton ML, Sorrentino JP, Yuen C, Mehta MM, Sharma G, Lin TL, Tran TM, Cohen A, Ritt… · 2025-11-27
cited 4× open access unreviewed -
10
Gene Flow Complicates Phylogenetic Inference in an Archipelago Radiation.
Gyllenhaal EF, Klicka LB, DeCicco LH, Weeks BC, Moyle RG, Andersen MJ. · 2026-06-01
cited 2× open access unreviewed
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